Evidence map›Paper›PMID 34224766›Full record

ArticleInternational journal of cardiology2021

Cardiac involvement in consecutive unselected hospitalized COVID-19 population: In-hospital evaluation and one-year follow-up.

Viviana Maestrini, Lucia Ilaria Birtolo, Marco Francone, Gioacchino Galardo, Nicola Galea, Paolo Severino, Francesco Alessandri, Maria Chiara Colaiacomo, Giulia Cundari, Cristina Chimenti and 13 more

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In one paragraph

Article in International journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025
    Pooled it
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  5. Long-Term Consequences of COVID-19 at 6 Months and Above: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
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  16. Post-COVID-19 syndrome: Cardiovascular manifestations.International journal of cardiology · 2022
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  19. The Management of Myocardial Injury Related to SARS-CoV-2 Pneumonia.Journal of cardiovascular development and disease · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Viviana MaestriniDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Lucia Ilaria BirtoloDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Marco FranconeDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy.
Gioacchino GalardoEmergency Department, "Policlinico Umberto I" Hospital, Rome, Italy.
Nicola GaleaDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Paolo SeverinoDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Francesco AlessandriDepartment of Anaesthesia and Intensive Care Medicine, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Maria Chiara ColaiacomoRadiology DEA Department, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Giulia CundariDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Cristina ChimentiDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Carlo LavalleDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Maria CiardiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Paolo PalangeDepartment of Public Health and Infectious Diseases, Division of Pulmonary Medicine, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Alberto Deales"Policlinico Umberto I" Hospital, Rome, Italy.
Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Claudio M MastroianniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Carlo CatalanoDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Franco RubertoDepartment of Anaesthesia and Intensive Care Medicine, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Francesco PuglieseDepartment of Anaesthesia and Intensive Care Medicine, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Giulia d'AmatiDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Francesco FedeleDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy.
Massimo ManconeDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Rome, Italy. Electronic address: massimo.mancone@uniroma1.it.
Policlinico Umberto I COVID-19 Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) can occur in COVID-19 and has impact on clinical course. Data on CVD prevalence in hospitalized COVID-19 patients and sequelae in survivors is limited. Aim of this prospective study carried out on consecutive unselected COVID-19 population, was to assess: 1) CVD occurrence among hospitalized COVID-19 patients, 2) persistence or new onset of CVD at one-month and one-year follow-up.

methodsOver 30 days n = 152 COVID-19 patients underwent cardiovascular evaluation. Standard electrocardiogram (ECG), Troponin and echocardiography were integrated by further tests when indicated. Medical history, arterial blood gas, blood tests, chest computed tomography and treatment were recorded. CVD was defined as the occurrence of a new condition during the hospitalization for COVID-19. Survivors attended a one-month follow-up visit and a one-year telephone follow-up.

resultsForty-two patients (28%) experienced a wide spectrum of CVD with acute myocarditis being the most frequent. Death occurred in 32 patients (21%) and more frequently in patients who developed CVD (p = 0.032). After adjustment for confounders, CVD was independently associated with death occurrence. At one-month follow-up visit, 7 patients (9%) presented persistent or delayed CVD. At one-year telephone follow-up, 57 patients (48%) reported persistent symptoms.

conclusionCardiovascular evaluation in COVID-19 patients is crucial since the occurrence of CVD in hospitalized COVID-19 patients is common (28%), requires specific treatment and increases the risk of in-hospital mortality. Persistence or delayed presentation of CVD at 1-month (9%) and persistent symptoms at 1-year follow-up (48%) suggest the need for monitoring COVID-19 survivors.

Indexed as

COVID-19MyocarditisFollow-Up StudiesHospitalsHumansProspective StudiesSARS-CoV-2Cardiovascular diseaseCardiovascular magnetic resonanceCOVID-19EchocardiographyFollow-upMyocarditis

Identifiers

PMID34224766
PMCPMC8253670

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.