Evidence map›Paper›PMID 34224603›Full record

ArticlePsycho-oncology2022

Greater financial toxicity relates to greater distress and worse quality of life among breast and gynecologic cancer survivors.

Catherine Benedict, Sophie Fisher, Lidia Schapira, Sabrina Chao, Sarah Sackeyfio, Tara Sullivan, Erqi Pollom, Jonathan S Berek, Allison W Kurian, Oxana Palesh

Open access · greenAbstract read
In one paragraph

Article in Psycho-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Evaluation of financial toxicity and associated factors in female patients with breast cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  4. Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  5. Quality of life and appraisal factors of patients with advanced cancer and their family caregivers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  12. The influence of family resilience and benefit finding on the financial toxicity of primary caregivers of patients with advanced cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  13. Financial toxicity among breast cancer survivors receiving care during the pandemic.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  14. Article
  15. Long-term quality of life, financial toxicity, and decision regret following therapeutic and prophylactic gastrectomy for cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  16. Financial toxicity trajectories and their association with short-term and long-term health outcomes in Chinese patients with cancer: a prospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Catherine BenedictStanford University School of Medicine, Palo Alto, California, USA.ORCID 0000-0001-9622-249X
Sophie FisherStanford University School of Medicine, Palo Alto, California, USA.
Lidia SchapiraStanford University School of Medicine, Palo Alto, California, USA.
Sabrina ChaoStanford University School of Medicine, Palo Alto, California, USA.
Sarah SackeyfioStanford University School of Medicine, Palo Alto, California, USA.
Tara SullivanStanford University School of Medicine, Palo Alto, California, USA.
Erqi PollomStanford University School of Medicine, Palo Alto, California, USA.
Jonathan S BerekStanford University School of Medicine, Palo Alto, California, USA.
Allison W KurianStanford University School of Medicine, Palo Alto, California, USA.
Oxana PaleshStanford University School of Medicine, Palo Alto, California, USA.
Cancer Prevention Institute of California · USPalo Alto University · US

Funding

Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related InsomniaR01CA239714 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI PALESH, OXANA G · 2020 to 2025
$4.5M
Brief Behavioral Intervention for Insomnia During ChemotherapyR01CA181659 · NCI · STANFORD UNIVERSITY · PI PALESH, OXANA G · 2014 to 2018
$3.1M
NCI NIH HHS R01 CA181659NCI NIH HHS R01 CA239714
6 · The paper itself

Abstract

backgroundFinancial toxicity includes distress and burden from cancer-related costs. Women are more likely to experience worse cancer-related financial outcomes than men. This study evaluated breast and gynecologic cancer patients' subjective experiences of financial toxicity and associations with distress and quality of life (QOL).

methodsA cross-sectional survey study included measures of financial toxicity (Comprehensive Score for Financial Toxicity [COST] Version 2), distress (Patient Health Questionnaire), and QOL (Functional Assessment of Cancer Therapy). Chi-square, t-tests, and ANOVAs examined bivariate relationships. Two regression models tested associations between financial toxicity and distress and QOL, controlling for covariates. Financial toxicity subgroups were compared based on a validated grading system.

resultsParticipants (N = 273; 74% breast cancer) averaged 54.65 years (SD = 12.08), were 3.42 years (SD = 4.20) post-diagnosis, and 33% reported cancer-related change in employment status. Financial toxicity was "mild" overall (COST M = 26.11, SD = 11.14); 32% worried about cancer-related financial problems (quite a bit/very much; item-level analysis). Worse financial toxicity related to younger age (p < 0.001), identifying as a non-Asian minority (p = 0.03) or Hispanic (p = 0.01), being single (p < 0.001), lower education (p = 0.004), lower income (p < 0.001), late-stage disease (p = 0.001), recurrent disease (p = 0.004), and active treatment (p < 0.001). In separate multivariable models, greater financial toxicity related to greater distress (β = -0.45 p < 0.001) and worse QOL (β = 0.58, p < 0.001). Financial toxicity subgroups reported clinically significant differences in distress and QOL (p's < 0.05).

conclusionsCancer-related financial burden is associated with pervasive negative effects and may impact subgroups differently. Future research should explore financial experiences across subgroups, aiming to better identify those at risk and build targeted interventions.

Indexed as

Cancer SurvivorsNeoplasmsCross-Sectional StudiesFemaleFinancial StressHumansMaleQuality of LifeSurvivorsbreast cancerfinancial hardshipfinancial stressfinancial toxicitygynecological cancerquality of life

Identifiers

PMID34224603
PMCPMC9809212
OpenAlexW3178974784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.