Evidence map›Paper›PMID 34224561›Full record

SynthesisThe American journal of clinical nutrition2021

Breastfeeding and risk of overweight in childhood and beyond: a systematic review with emphasis on sibling-pair and intervention studies.

Kathryn G Dewey, Darcy Güngör, Sharon M Donovan, Emily M Madan, Sudha Venkatramanan, Teresa A Davis, Ronald E Kleinman, Elsie M Taveras, Regan L Bailey, Rachel Novotny and 5 more

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Kathryn G DeweyDepartment of Nutrition, University of California, Davis, CA, USA.
Darcy GüngörPanum Group, Bethesda, MD, USA.ORCID 0000-0001-7879-7636
Sharon M DonovanDepartment of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, IL, USA.
Emily M MadanPanum Group, Bethesda, MD, USA.
Sudha VenkatramananPanum Group, Bethesda, MD, USA.
Teresa A DavisUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Ronald E KleinmanMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Elsie M TaverasMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Regan L BaileyDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Rachel NovotnyDepartment of Human Nutrition Food and Animal Sciences, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Manoa, HI, USA.
Nancy TerryNational Institutes of Health Library, Office of Research Services, US Department of Health and Human Services (HHS), Bethesda, MD, USA.
Gisela ButeraPanum Group, Bethesda, MD, USA.
Julie ObbagyNutrition Evidence Systematic Review team, Nutrition Guidance and Analysis Division (NGAD), Center for Nutrition Policy and Promotion (CNPP), Food and Nutrition Service (FNS), US Department of Agriculture (USDA), Alexandria, VA, USA.ORCID 0000-0001-8116-9622
Janet de JesusOffice of Disease Prevention and Health Promotion, HHS, Rockville, MD, USA.ORCID 0000-0002-4025-0675
Eve StoodyNGAD, CNPP, FNS, USDA, Alexandria, VA, USA.ORCID 0000-0003-2510-9005
Center for Nutrition Policy and Promotion · USHarvard University · USChildren's Nutrition Research Center at Baylor College of Medicine · USNational Institutes of Health · USOffice of Disease Prevention and Health Promotion · USPurdue University West Lafayette · USUniversity of California, Davis · USUniversity of Hawaiʻi at Mānoa · USUniversity of Illinois Urbana-Champaign · US

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
NIDDK NIH HHS P30 DK111022
6 · The paper itself

Abstract

backgroundBreastfeeding is associated with a lower risk of subsequent overweight or obesity, but it is uncertain whether this is a causal relation because most studies have not adequately reduced risk of bias due to confounding.

objectivesThe aim of this review was to examine whether 1) ever compared with never consuming human milk and 2) different durations of human milk consumption among infants fed human milk are related to later risk of overweight or obesity, with emphasis on sibling-pair and intervention studies.

methodsThe 2020 Dietary Guidelines Advisory Committee, together with the Nutrition Evidence Systematic Review team, conducted a systematic review of articles relevant to healthy full-term infants in countries with a high or very high level of human development. We searched PubMed, Embase, Cochrane, and CINAHL; dual-screened the results using predetermined criteria; extracted data from and assessed the risk of bias for each included study; qualitatively synthesized the evidence; developed conclusion statements; and graded the strength of the evidence.

resultsThe review included 42 articles, including 6 cohorts with sibling-pair analyses and 1 randomized controlled trial of a breastfeeding promotion intervention. Moderate evidence suggested that ever, compared with never, consuming human milk is associated with a lower risk of overweight and obesity at ages 2 y and older, particularly if the duration of human milk consumption is >6 mo. However, residual confounding cannot be ruled out. Evidence was insufficient to determine the relation between the duration of any human milk consumption, among infants fed human milk, and overweight and/or obesity at age 2 y and older.

conclusionsFurther research, using strong study designs, is needed to disentangle the complex relation between infant feeding practices and the risk of subsequent overweight or obesity, as well as the biological and behavioral mechanisms if the relation is causal.

Indexed as

Breast FeedingAdolescentAdolescent HealthAdultChildChild DevelopmentChild, PreschoolHumansInfantOverweightPediatric Obesitybreastfeedingchildhuman milkinfantobesityoverweightsiblingsystematic reviewtoddler

Identifiers

PMID34224561
PMCPMC8830309
OpenAlexW3177883542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.