Evidence map›Paper›PMID 34224309›Full record

ArticleGut microbes

The commensal bacterium

Aize Pellon, Diego Barriales, Ainize Peña-Cearra, Janire Castelo-Careaga, Ainhoa Palacios, Nerea Lopez, Estibaliz Atondo, Miguel Angel Pascual-Itoiz, Itziar Martín-Ruiz, Leticia Sampedro and 15 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Probiotics as Potential Enhancers of Veterinary Vaccines.Probiotics and antimicrobial proteins · 2026
    Review
  2. Review
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  5. Membrane Vesicles fromInternational journal of molecular sciences · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Pleiotropic Mucosal Innate Immune Memory in the Gastrointestinal Tract.International journal of molecular sciences · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Recent Advances of Trained immunity in Macrophages.International journal of biological sciences · 2025
    Review
  16. Review
  17. Review
  18. Inhibition ofmSphere · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 2 countries.

Aize PellonInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.ORCID 0000-0003-0415-6566
Diego BarrialesInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.ORCID 0000-0002-6433-3379
Ainize Peña-CearraInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Janire Castelo-CareagaInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Ainhoa PalaciosInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Nerea LopezInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Estibaliz AtondoInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Miguel Angel Pascual-ItoizInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Itziar Martín-RuizInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Leticia SampedroInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Monika Gonzalez-LopezGenomic Analysis Platform, CIC bioGUNE-BRTA, Derio, Spain.
Laura BárcenaGenomic Analysis Platform, CIC bioGUNE-BRTA, Derio, Spain.
Teresa Martín-MateosPhysiopathology of the Hypoxia-signaling Pathway Laboratory, CIC bioGUNE-BRTA, Derio, Spain.
Jose María LandeteDepartamento De Tecnología De Alimentos, Instituto Nacional De Investigación Y Tecnología Agraria Y Alimentaria (INIA), Madrid, Spain.
Rafael Prados-RosalesInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Laura Plaza-VinuesaLaboratorio De Biotecnología Bacteriana, Instituto De Ciencia Y Tecnología De Alimentos Y Nutrición (ICTAN-CSIC), Madrid, Spain.
Rosario MuñozLaboratorio De Biotecnología Bacteriana, Instituto De Ciencia Y Tecnología De Alimentos Y Nutrición (ICTAN-CSIC), Madrid, Spain.
Blanca de Las RivasLaboratorio De Biotecnología Bacteriana, Instituto De Ciencia Y Tecnología De Alimentos Y Nutrición (ICTAN-CSIC), Madrid, Spain.
Juan Miguel RodríguezDepartment of Nutrition and Food Science, Universidad Complutense De Madrid, Madrid, Spain.
Edurne BerraPhysiopathology of the Hypoxia-signaling Pathway Laboratory, CIC bioGUNE-BRTA, Derio, Spain.
Ana M AransayGenomic Analysis Platform, CIC bioGUNE-BRTA, Derio, Spain.
Leticia AbeciaInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.ORCID 0000-0003-4097-8903
Jose Luis LavínBioinformatics Unit, CIC bioGUNE-BRTA, Derio, Spain.
Hector RodríguezInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.ORCID 0000-0002-9948-2497
Juan AnguitaInflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.ORCID 0000-0003-2061-7182
CIC bioGUNE · ESInstituto de Ciencia y Tecnología de Alimentos y Nutrición · ESKing's College London · GBUniversity of the Basque Country · ESIkerbasque · ESInstituto de Salud Carlos III · ESInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota is a constant source of antigens and stimuli to which the resident immune system has developed tolerance. However, the mechanisms by which mononuclear phagocytes, specifically monocytes/macrophages, cope with these usually pro-inflammatory signals are poorly understood. Here, we show that innate immune memory promotes anti-inflammatory homeostasis, using as model strains of the commensal bacterium

Indexed as

Immunity, InnateAdultAgedAnimalsAntimicrobial PeptidesFemaleHumansImmunologic MemoryInterleukin-10LactobacillaceaeMacrophagesMaleMiceMicrobiotaMiddle AgedMonocytesAntimicrobial PeptidesInterleukin-10immunometabolisminnate immune memoryLactiplantibacillus plantarumLactobacillusmacrophagesmicrobiotamonocytestrained immunity

Identifiers

PMID34224309
PMCPMC8259724
OpenAlexW3181569842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.