Evidence map›Paper›PMID 34224249›Full record

ReviewThe neuroradiology journal2021

Delayed leukoencephalopathy from suspected polymer embolism after neuroendovascular procedures.

Thomas Mellemkjær, Ronil V Chandra, Lasse Speiser, Benedicte P Ulhøi, Claus Z Simonsen

Abstract readReview
In one paragraph

Review in The neuroradiology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thomas MellemkjærDepartment of Neurology, 11297Aarhus University Hospital, Aarhus University Hospital, Denmark.ORCID https://orcid.org/0000-0003-3109-2561
Ronil V ChandraNeuroInterventional Radiology, 2541Monash University, School of Clinical Sciences at Monash Health, Monash University, Australia.
Lasse SpeiserDepartment of Neuroradiology, 11297Aarhus University Hospital, Aarhus University Hospital, Denmark.
Benedicte P UlhøiDepartment Pathology, 11297Aarhus University Hospital, Aarhus University Hospital, Denmark.
Claus Z SimonsenDepartment of Neurology, 11297Aarhus University Hospital, Aarhus University Hospital, Denmark.ORCID https://orcid.org/0000-0003-1363-0266

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the neurointervention field grows, a new side effect emerges. Delayed leukoencephalopathy (DL) is believed to be an inflammatory or allergic reaction to polymer material that is shed from catheters during endovascular procedures. We present four cases of DL after aneurysm treatment in two patients, endovascular stroke treatment and diagnostic arteriography. We present our diagnostic process, including biopsy results in two patients, our anti-inflammatory treatment and outcomes together with a review of the literature. In our series, prognosis was variable with ongoing seizures in two patients. Our literature review reveals that asymptomatic shedding of polymer material is common, occurring in a third of endovascular stroke procedures, whereas symptomatic DL occurs in <0.5% of therapeutic neuroendovascular procedures. Clinicians should be aware of this rare complication, and oral glucocorticoids seem to be a reasonable first-line treatment strategy.

Indexed as

EmbolismEndovascular ProceduresLeukoencephalopathiesStrokeHumansPolymersTreatment OutcomePolymerscomplicationencephalitisEndovascular therapyinflammation

Identifiers

PMID34224249
PMCPMC8447825

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.