Evidence map›Paper›PMID 34224153›Full record

ArticleMedical physics2021

Generation of synthetic PET images of synaptic density and amyloid from

Rui Wang, Hui Liu, Takuya Toyonaga, Luyao Shi, Jing Wu, John Aaron Onofrey, Yu-Jung Tsai, Mika Naganawa, Tianyu Ma, Yaqiang Liu and 6 more

Abstract read
In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. A deep learning model for generating [European journal of nuclear medicine and molecular imaging · 2024
    Article
  11. Article
  12. Machine learning methods for tracer kinetic modelling.Nuklearmedizin. Nuclear medicine · 2023
    Review
  13. Generation of Whole-Body FDG ParametricIEEE transactions on radiation and plasma medical sciences · 2023
    Article
  14. Review
  15. A review on AI in PET imaging.Annals of nuclear medicine · 2022
    Review
  16. Synthetic O-(2-Neuro-oncology advances
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rui WangDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Hui LiuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Luyao ShiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Jing WuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
John Aaron OnofreyDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Yu-Jung TsaiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Mika NaganawaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Tianyu MaDepartment of Engineering Physics, Tsinghua University, Beijing, China.
Yaqiang LiuDepartment of Engineering Physics, Tsinghua University, Beijing, China.
Ming-Kai ChenDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Adam P MeccaDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Ryan S O'DellDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Christopher H van DyckDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Chi LiuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER, CHRISTOPHER H VAN DYCK · 2020 to 2026
$30.2M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The Aging Brain: Vasculature, Ischemia, and BehaviorP01AG012435 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WEINER, MICHAEL W · 1994 to 2012
$26.4M
PET Imaging of SV2A and Other Biomarkers in Alzheimer's DiseaseR01AG062276 · NIA · YALE UNIVERSITY · PI VAN DYCK, CHRISTOPHER H · 2018 to 2022
$5.5M
PET Imaging of Synaptic Density in Alzheimers DiseaseR01AG052560 · NIA · YALE UNIVERSITY · PI CARSON, RICHARD E., VAN DYCK, CHRISTOPHER H · 2017 to 2020
$3.2M
Quantitative Low-Dose PET ImagingR01EB025468 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LIU, CHI · 2018 to 2022
$3.2M
SV2A PET Imaging in Healthy Subjects and Epilepsy PatientsR01NS094253 · NINDS · YALE UNIVERSITY · PI CARSON, RICHARD E. · 2016 to 2020
$2.8M
Investigation of molecular changes in mGluR5 and SV2A to study synaptic alterations in Alzheimer's disease using PET.K23AG057794 · NIA · YALE UNIVERSITY · PI MECCA, ADAM PETER · 2018 to 2022
$977k
China Scholar CouncilNCATS NIH HHS UL1 TR001863NIA NIH HHS K23 AG057794NIA NIH HHS P01 AG012435NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG052560NIA NIH HHS R01 AG062276NIBIB NIH HHS R01 EB025468NIH HHS P30AG066508NIH HHS R01AG052560NIH HHS R01AG062276NIH HHS R01EB025468NIH HHS R01NS094253NINDS NIH HHS R01 NS094253
6 · The paper itself

Abstract

purposePositron emission tomography (PET) imaging with various tracers is increasingly used in Alzheimer's disease (AD) studies. However, access to PET scans using new or less-available tracers with sophisticated synthesis and short half-life isotopes may be very limited. Therefore, it is of great significance and interest in AD research to assess the feasibility of generating synthetic PET images of less-available tracers from the PET image of another common tracer, in particular

methodsWe implemented advanced deep learning methods using the U-Net model to predict

resultsThe results showed that all four network models obtained satisfactory

conclusionsIt is feasible to use 3D U-Net-based methods to generate synthetic

Indexed as

Alzheimer DiseaseDeep LearningAniline CompoundsBrainFluorodeoxyglucose F18HumansPositron-Emission TomographyAniline CompoundsFluorodeoxyglucose F18brain PETdeep learningimage processingmulti-tracerparametric image

Identifiers

PMID34224153
PMCPMC8455448

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.