ArticleProceedings of the National Academy of Sciences of the United States of America1988
Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 262 citations in OpenAlex.
- Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and Therapeutic Strategies.Molecular neurobiology · 2025Review
- Dynamics of Neurogenic Signals as Biological Switchers of Brain Plasticity.Stem cell reviews and reports · 2024Review
- Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus.Fluids and barriers of the CNS · 2024Article
- Regulation of trophic factors in the choroid plexus of aged mice.Research square · 2024Article
- Article
- Insulin-like growth factor-2 is a promising candidate for the treatment and prevention of Alzheimer's disease.CNS neuroscience & therapeutics · 2023Review
- Novel model of cortical-meningeal organoid co-culture system improves human cortical brain organoid cytoarchitecture.Scientific reports · 2023Article
- Insulin-like Growth Factor-2 (IGF-2) in Fibrosis.Biomolecules · 2022Review
- A preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma.Neuro-oncology · 2022Article
- A preliminary study on the development of a novel biomatrix by decellularization of bovine spinal meninges for tissue engineering applications.Cell and tissue banking · 2021Article
- Insulin-Like Growth Factor 2 As a Possible Neuroprotective Agent and Memory Enhancer-Its Comparative Expression, Processing and Signaling in Mammalian CNS.International journal of molecular sciences · 2021Review
- Review
- Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development.Developmental biology · 2020Article
- Inference of Diagnostic Markers and Therapeutic Targets From CSF Proteomics for the Treatment of Hydrocephalus.Frontiers in cellular neuroscience · 2020Article
- Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides.Neuron · 2019Article
- Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine.Stem cell reports · 2019Article
- Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging.Aging and disease · 2019Article
- Non-islet Cell Hypoglycemia: Case Series and Review of the Literature.Frontiers in endocrinology · 2019Article
- A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side.Journal of visualized experiments : JoVE · 2016Article
- Insulin and IGF receptor signalling in neural-stem-cell homeostasis.Nature reviews. Endocrinology · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rat insulin-like growth factor II gene, encoding a fetal somatomedin, expresses a multitranscript family in embryonic/fetal tissues and in the adult brain and spinal cord. By performing in situ hybridization on tissue sections of adult brain and spinal cord, we have found that these transcripts are not expressed in neural or glial cells but are expressed in the epithelium of the choroid plexus of each cerebral ventricle and in the leptomeninges. We propose that the choroidal epithelial cells synthesize and secrete insulin-like growth factor II into the cerebrospinal fluid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.