Evidence map›Paper›PMID 34224044›Full record

ArticleAnnals of surgical oncology2021

Development and Psychometric Validation of a Patient-Reported Outcome Measure for Arm Lymphedema: The LYMPH-Q Upper Extremity Module.

Anne F Klassen, Elena Tsangaris, Manraj N Kaur, Lotte Poulsen, Louise M Beelen, Amalie Lind Jacobsen, Mads Gustaf Jørgensen, Jens Ahm Sørensen, Dalibor Vasilic, Joseph Dayan and 2 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05441943 (Lymphaticovenous Anastomosis as a Surgical Treatment for Breast Cancer-Related Lymphedema), which is not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05441943 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Lymphaticovenous Anastomosis as a Surgical Treatment for Breast Cancer-Related Lymphedema

TypeinterventionalSponsorOdense University HospitalRan2022 to 2026Enrolled10ConditionsBreast Cancer Lymphedema, Secondary Lymphedema, Iatrogenic Lymphedema, LymphedemaArmsLymphovenous anastomosis
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Anne F KlassenMcMaster University, Hamilton, ON, Canada. aklass@mcmaster.ca.
Elena TsangarisBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Manraj N KaurBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lotte PoulsenResearch Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark.
Louise M BeelenBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Amalie Lind JacobsenResearch Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark.
Mads Gustaf JørgensenResearch Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark.
Jens Ahm SørensenResearch Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark.
Dalibor VasilicDepartment of Plastic, Reconstructive and Hand Surgery, ErasmusMC, Rotterdam, The Netherlands.
Joseph DayanMemorial Sloan-Kettering Cancer Center, New York, USA.
Babak MehraraMemorial Sloan-Kettering Cancer Center, New York, USA.
Andrea L PusicBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USOdense University Hospital · DKMemorial Sloan Kettering Cancer Center · USBrigham and Women's Hospital · USErasmus University Rotterdam · NLMcMaster University · CAUniversity of Southern Denmark · DK

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Canadian Breast Cancer Foundation 319371Canadian Cancer Society Research Institute 706256NCI NIH HHS P30 CA008748NCI NIH HHS P30CA008748
6 · The paper itself

Abstract

backgroundA multiphased mixed-methods study was performed to develop and validate a comprehensive patient-reported outcome measure (PROM) for arm lymphedema in women with breast cancer (i.e., the LYMPH-Q Upper Extremity Module).

methodsQualitative interviews (January 2017 and June 2018) were performed with 15 women to elicit concepts specific to arm lymphedema after breast cancer treatment. Data were audio-recorded, transcribed, and coded. Scales were refined through cognitive interviews (October and Decemeber 2018) with 16 patients and input from 12 clinical experts. The scales were field-tested (October 2019 and January 2020) with an international sample of 3222 women in the United States and Denmark. Rasch measurement theory (RMT) analysis was used to examine reliability and validity.

resultsThe qualitative phase resulted in six independently functioning scales that measure arm symptoms, function, appearance, psychological function, and satisfaction with information and with arm sleeves. In the RMT analysis, all items in each scale had ordered thresholds and nonsignificant chi-square p values. For all the scales, the reliability statistics with and without extremes for the Person Separation Index were 0.80 or higher, Cronbach's alpha was 0.89 or higher, and the Intraclass Correlation Coefficients were 0.92 or higher. Lower (worse) scores on the LYMPH-Q Upper Extremity scales were associated with reporting of more severe arm swelling, an arm problem caused by cancer and/or its treatment, and wearing of an arm sleeve in the past 12 months.

conclusionsThe LYMPH-Q Upper Extremity Module can be used to measure outcomes that matter to women with upper extremity lymphedema. This new PROM was designed using a modern psychometric approach and, as such, can be used in research and in clinical care.

Indexed as

ArmLymphedemaFemaleHumansPatient Reported Outcome MeasuresPatient SatisfactionPsychometricsQuality of LifeReproducibility of ResultsSurveys and QuestionnairesUpper Extremity

Identifiers

PMID34224044
PMCPMC8349351
OpenAlexW3180405488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.