Evidence map›Paper›PMID 34223954›Full record

ArticleEuropean radiology2022

Artificial intelligence for prediction of COVID-19 progression using CT imaging and clinical data.

Robin Wang, Zhicheng Jiao, Li Yang, Ji Whae Choi, Zeng Xiong, Kasey Halsey, Thi My Linh Tran, Ian Pan, Scott A Collins, Xue Feng and 24 more

Abstract readMulticenter Study
In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Radiomics analysis in medical imaging research.Journal of medical radiation sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Robin Wang *Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Zhicheng Jiao *Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Li YangDepartment of Neurology, Second Xiangya Hospital, Central South University, Changsha, China.
Ji Whae ChoiDepartment of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, 02903, USA.
Zeng XiongDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Kasey HalseyDepartment of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, 02903, USA.
Thi My Linh TranDepartment of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, 02903, USA.
Ian PanDepartment of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, 02903, USA.
Scott A CollinsDepartment of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, 02903, USA.
Xue FengCarina Medical, Carina, Australia.
Jing WuDepartment of Radiology, Second Xiangya Hospital, Central South University, Changsha, China.
Ken ChangMassachusetts Institute of Technology, Cambridge, MA, USA.
Lin-Bo ShiDepartment of Radiology, Yongzhou Central Hospital, Yongzhou, China.
Shuai YangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Qi-Zhi YuDepartment of Radiology, The First Hospital of Changsha, Changsha, China.
Jie LiuDepartment of Radiology, Changde Second People's Hospital, Changde, China.
Fei-Xian FuDepartment of Radiology, Yiyang City Center Hospital, Yiyang, China.
Xiao-Long JiangDepartment of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, China.
Dong-Cui WangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Li-Ping ZhuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Xiao-Ping YiDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Terrance T HealeyDepartment of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, 02903, USA.
Qiu-Hua ZengDepartment of Radiology, Loudi Central Hospital, Loudi, China.
Tao LiuBrown University School of Public Health, Providence, RI, USA.
Ping-Feng HuDepartment of Radiology, Chenzhou Second People's Hospital, Chenzhou, China.
Raymond Y HuangDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Yi-Hui LiDepartment of Radiology, Zhuzhou Central Hospital, Zhuzhou, China.
Ronnie A SebroDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Paul J L ZhangDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jianxin WangSchool of Computer Science and Engineering, Central South University, Changsha, China.
Michael K AtalayDepartment of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, 02903, USA.
Wei-Hua LiaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China. owenliao@csu.edu.cn.
Yong FanDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Harrison X BaiDepartment of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, 02903, USA. harrison_bai@brown.edu.ORCID http://orcid.org/0000-0002-9614-2163

Funding

Personalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0M
Neuroimaging Training ProgramT32EB001680 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BRUCE R ROSEN · 2003 to 2026
$3.8M
Learning radiomic signatures to early predict response of rectal cancer patients to neoadjuvant chemoradiation therapyR21CA223358 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG · 2018 to 2019
$380k
Deep learning for renal tumor characterizationR03CA249554 · NCI · RHODE ISLAND HOSPITAL · PI BAI, HARRISON · 2020 to 2021
$162k
Automatic Volumetric Treatment Response Assessment and Determination of Regional Genetic Characteristics in GlioblastomaF30CA239407 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHANG, KEN · 2019 to 2020
$101k
National Cancer Institute (NCI) of the National Institutes of Health F30CA239407National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health 5T32EB1680National Institutes of Health/National Cancer Institute CA223358National Institutes of Health/National Cancer Institute DK117297National Institutes of Health/National Cancer Institute EB022573National Institutes of Health/National Cancer Institute MH120811National Institutes of Health/National Cancer Institute R03CA249554NCI NIH HHS F30 CA239407NIBIB NIH HHS R01 EB022573NIBIB NIH HHS T32 EB001680RSNA Research and Education Foundation (US) RSCH2004
6 · The paper itself

Abstract

objectivesEarly recognition of coronavirus disease 2019 (COVID-19) severity can guide patient management. However, it is challenging to predict when COVID-19 patients will progress to critical illness. This study aimed to develop an artificial intelligence system to predict future deterioration to critical illness in COVID-19 patients.

methodsAn artificial intelligence (AI) system in a time-to-event analysis framework was developed to integrate chest CT and clinical data for risk prediction of future deterioration to critical illness in patients with COVID-19.

resultsA multi-institutional international cohort of 1,051 patients with RT-PCR confirmed COVID-19 and chest CT was included in this study. Of them, 282 patients developed critical illness, which was defined as requiring ICU admission and/or mechanical ventilation and/or reaching death during their hospital stay. The AI system achieved a C-index of 0.80 for predicting individual COVID-19 patients' to critical illness. The AI system successfully stratified the patients into high-risk and low-risk groups with distinct progression risks (p < 0.0001).

conclusionsUsing CT imaging and clinical data, the AI system successfully predicted time to critical illness for individual patients and identified patients with high risk. AI has the potential to accurately triage patients and facilitate personalized treatment. KEY POINT: • AI system can predict time to critical illness for patients with COVID-19 by using CT imaging and clinical data.

Indexed as

COVID-19Artificial IntelligenceHumansRetrospective StudiesSARS-CoV-2Tomography, X-Ray ComputedCoronavirus infectionsDeep learningDisease progressionHelical CT

Identifiers

PMID34223954
PMCPMC8256200

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.