ArticleArchives of Razi Institute2021
Enhancement of Productive Performance, Bone Physical Characteristics, and Mineralization of Laying Hens during the Post-Peak Period by Genistein.
Article in Archives of Razi Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Soybean isoflavones enhance production and albumen quality in aged laying hens by modulating ovarian function, immunity, and antioxidant capacity.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effects of 3',4'-dihydroxyflavonol treatment on Neu N and BDNF and ICAM levels in the striatum of rats subjected to transient bilateral carotid occlusion-induced ischemia-reperfusion.Journal of bioenergetics and biomembranes · 2026Article
- Dietary genistein supplementation enhances reproductive and bone health in late-laying hens.Poultry science · 2026Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genistein (GEN), a soybean isoflavone, is structurally and functionally similar to endogenous estrogen; therefore, it has the potential to enhance estradiol properties. This study aimed to evaluate the effects of GEN on the reproductive performance and bone status of laying hens. In total, 80 Hy-line W-36 (40 weeks old, the late stage of egg production cycle) with an initial body weight of 1,230±15.8 g (Mean±S.E.M), similar egg production, and egg weight were randomly assigned into two groups with 10 replicates and 4 birds in each replicate (40 laying hens per group). Laying hen diets had 0 (control) and 20 mg/kg GEN (white powder, Sichuan Guanghan co. Ltd., purity of 98.5%) for 6 weeks (41 to 46). At the end of the experiment, 20 hens (one hen from each replicate) were slaughtered, and the samples of bone and shell gland (approximately 50 mg) were surgically taken immediately after slaughter for Real-time PCR. The results indicated that dietary GEN increased egg production, feed intake, and egg mass; however, it decreased egg weight (p <0.05). Furthermore, the feed conversion ratio was greater in birds received GEN, compared to those in the control group (p <0.05). GEN enhanced egg quality indices included eggshell strength, thickness, and percentage (p <0.05). Mechanical properties of the tibia, such as weight, length, and breaking strength were also increased by GEN (p <0.05). Moreover, dietary GEN increased the calcium content of the tibia (p <0.05). The mRNA expression of Calbindin-D28k (CaBP-D28k) and transient receptor potential vanilloid channel type 6 (TRPV6) upregulated in eggshell glands of hens treated with GEN paralleled to the controls (p <0.05). In conclusion, the findings of the present study showed that GEN had the potential to improve the bone physical characteristics, mineralization, and the productive performance of Hy-line W-36 laying hens in their post-peak period.
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