ArticleBiomaterials science2021
Stretch-responsive adhesive microcapsules for strain-regulated antibiotic release from fabric wound dressings.
Article in Biomaterials science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Shape-morphing active particles with invertible effective polarizability for configurable locomotion and steering.Nature communications · 2026Article
- Recent Advances of Microcapsule-based Intelligent Coatings: From Bioinspired Designs, Material Selections, to Potential Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- SCO-ph: Microfluidic Dynamic Phenotyping Platform for High-Throughput Screening of Single Cell Acidification.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Artificial Intelligence-Empowered Automated Double Emulsion Droplet Library Generation.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- A microfluidic platform for the synthesis of polymer and polymer-protein-based protocells.The European physical journal. E, Soft matter · 2024Article
- Drug-loaded adhesive microparticles for biofilm prevention on oral surfaces.Journal of materials chemistry. B · 2024Article
- Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections.Biomedicines · 2024Review
- Bioenergy-Based Closed-Loop Medical Systems for the Integration of Treatment, Monitoring, and Feedback.Small science · 2023Article
- Fabrication, Characterization, and In Vitro Cytotoxicity Assessment of Tri-Layered Multifunctional Scaffold for Effective Chronic Wound Healing.Bioengineering (Basel, Switzerland) · 2023Article
- Temperature controlled microcapsule loaded withFrontiers in nutrition · 2023Article
- Identifying small molecules for protecting chondrocyte function and matrix integrity after controlled compressive injury.Osteoarthritis and cartilage open · 2022Article
- Gravity-based patterning of osteogenic factors to preserve bone structure after osteochondral injury in a large animal model.Biofabrication · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Bacterial infection of a wound is a major complication that can significantly delay proper healing and even necessitate surgical debridement. Conventional non-woven fabric dressings, including gauzes, bandages and cotton wools, often fail in treating wound infections in a timely manner due to their passive release mechanism of antibiotics. Here, we propose adhesive mechanically-activated microcapsules (MAMCs) capable of strongly adhering to a fibrous matrix to achieve a self-regulated release of antibiotics upon uniaxial stretching of non-woven fabric dressings. To achieve this, a uniform population of polydopamine (PDA)-coated MAMCs (PDA-MAMCs) are prepared using a microfluidics technique and subsequent oxidative dopamine polymerization. The PDA-MAMC allows for robust mechano-activation within the fibrous network through high retention and effective transmission of mechanical force under stretching. By validating the potential of a PDA-MAMCs-laden gauze to release antibiotics in a tensile strain-dependent manner, we demonstrate that PDA-MAMCs can be successfully incorporated into a woven material and create a smart wound dressing for control of bacterial infections. This new mechano-activatable delivery approach will open up a new avenue for a stretch-triggered, on-demand release of therapeutic cargos in skin-mountable or wearable biomedical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.