ArticleNeurotrauma reports2020
Polytrauma Is Associated with Increased Three- and Six-Month Disability after Traumatic Brain Injury: A TRACK-TBI Pilot Study.
Article in Neurotrauma reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Influence of multiple trauma on the effect of transfusion strategies in patients with traumatic brain injury: a sub-study of the HEMOTION trial.Intensive care medicine · 2026Trial
- Multidimensional Preinjury Health and 6-month Outcome After Traumatic Brain Injury in Older Adults Presenting With Mainly GCS 13-15.The Journal of head trauma rehabilitation · 2026Article
- Article
- Impact of Delayed Trauma Unit Admission on Mortality and Disability in Traumatic Brain Injury Patients.International journal of environmental research and public health · 2025Observational
- Acute Surgery vs Conservative Treatment for Traumatic Acute Subdural Hematoma.JAMA network open · 2025Observational
- Isolated abducens nerve involvement as a revealing sign of temporal bone fracture: A case report.Radiology case reports · 2025Article
- Genetic Differences Modify Anesthetic Preconditioning of Traumatic Brain Injury in Drosophila.Journal of neurotrauma · 2025Article
- Return to work 10 years after severe trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Clinical Assessment on Days 1-14 for the Characterization of Traumatic Brain Injury: Recommendations from the 2024 NINDS Traumatic Brain Injury Classification and Nomenclature Initiative Clinical/Symptoms Working Group.Journal of neurotrauma · 2025Review
- Post-Traumatic Stress Disorder in ICU Survivors: Correlations with Long-Term Psychiatric and Physical Outcomes.International journal of environmental research and public health · 2025Article
- How Are TBI Symptoms Interconnected? A Network Analysis Approach.Brain and behavior · 2025Article
- Traumatic brain injury induces DNA damage in Drosophila.microPublication biology · 2025Article
- Risk reduction after bicycle, scooter, and skateboard-related head injuries through helmet use and brain injury education: A trauma center quality improvement initiative.Brain & spine · 2025Article
- Early GFAP and UCH-L1 point-of-care biomarker measurements for the prediction of traumatic brain injury and progression in patients with polytrauma and hemorrhagic shock.Journal of neurosurgery · 2024Article
- Symptomatic Recovery from Concussion in Military Service Members with and Without Associated Bodily Injuries.Neurotrauma reports · 2024Article
- Data-driven distillation and precision prognosis in traumatic brain injury with interpretable machine learning.Scientific reports · 2023Article
- Power Drill Craniostomy for Bedside Intracranial Access in Traumatic Brain Injury Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Traumatic Brain Injury: Contemporary Challenges and the Path to Progress.Journal of clinical medicine · 2023Article
- Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study.Journal of clinical medicine · 2023Article
- Factors affecting occupational therapy services for patients with traumatic brain injury.African journal of disability · 2023Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Funding
Abstract
Polytrauma and traumatic brain injury (TBI) frequently co-occur and outcomes are routinely measured by the Glasgow Outcome Scale-Extended (GOSE). Polytrauma may confound GOSE measurement of TBI-specific outcomes. Adult patients with TBI from the prospective Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study had presented to a Level 1 trauma center after injury, received head computed tomography (CT) within 24 h, and completed the GOSE at 3 months and 6 months post-injury. Polytrauma was defined as an Abbreviated Injury Score (AIS) ≥3 in any extracranial region. Univariate regressions were performed using known GOSE clinical cutoffs. Multi-variable regressions were performed for the 3- and 6-month GOSE, controlling for known demographic and injury predictors. Of 361 subjects (age 44.9 ± 18.9 years, 69.8% male), 69 (19.1%) suffered polytrauma. By Glasgow Coma Scale (GCS) assessment, 80.1% had mild, 5.8% moderate, and 14.1% severe TBI. On univariate logistic regression, polytrauma was associated with increased odds of moderate disability or worse (GOSE ≤6; 3 month odds ratio [OR] = 2.57 [95% confidence interval (CI): 1.50-4.41; 6 month OR = 1.70 [95% CI: 1.01-2.88]) and death/severe disability (GOSE ≤4; 3 month OR = 3.80 [95% CI: 2.03-7.11]; 6 month OR = 3.33 [95% CI: 1.71-6.46]). Compared with patients with isolated TBI, more polytrauma patients experienced a decline in GOSE from 3 to 6 months (37.7 vs. 24.7%), and fewer improved (11.6 vs. 22.6%). Polytrauma was associated with greater univariate ordinal odds for poorer GOSE (3 month OR = 2.79 [95% CI: 1.73-4.49]; 6 month OR = 1.73 [95% CI: 1.07-2.79]), which was conserved on multi-variable ordinal regression (3 month OR = 3.05 [95% CI: 1.76-5.26]; 6 month OR = 2.04 [95% CI: 1.18-3.42]). Patients with TBI with polytrauma are at greater risk for 3- and 6-month disability compared with those with isolated TBI. Methodological improvements in assessing TBI-specific disability, versus disability attributable to all systemic injuries, will generate better TBI outcomes assessment tools.
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