Evidence map›Paper›PMID 34223394›Full record

ArticleResuscitation plus2021

Ultra-early serum concentrations of neuronal and astroglial biomarkers predict poor neurological outcome after out-of-hospital cardiac arrest-a pilot neuroprognostic study.

Karl W Huesgen, Yasmeen O Elmelige, Zhihui Yang, Muhammad Abdul Baker Chowdhury, Sarah Gul, Carolina B Maciel, Marie-Carmelle Elie-Turenne, Torben K Becker, Scott A Cohen, Amy Holland and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05000320 (VIGAB-BIOSTAT), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05000320 withdrawnnot on this mapstarted 2023, after this paper: background citation

VIGAB-BIOSTAT: Neuronal Injury Panel Substudy

TypeobservationalSponsorUniversity of FloridaRan2023 to 2024Enrolled0ConditionsStatus Epilepticus, Cardiac Arrest With Successful ResuscitationArmsNeuronal Injury Panel
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Observational
  5. Review
  6. Fluid Biomarkers for Monitoring Structural Changes in Polyneuropathies: Their Use in Clinical Practice and Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Karl W HuesgenDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Yasmeen O ElmeligeDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Zhihui YangProgram for Neurotrauma, Neuroproteomics & Biomarker Research, McKnight Brain Institute, University of Florida, 1149 Newell Drive, Gainesville, FL 32610, USA.
Muhammad Abdul Baker ChowdhuryDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Sarah GulDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Carolina B MacielDepartment of Neurology, University of Florida, 1149 Newell Drive, Gainesville, FL 32611, USA.
Marie-Carmelle Elie-TurenneDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Torben K BeckerDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Scott A CohenDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Amy HollandDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Cindy MonteroDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Tian ZhuProgram for Neurotrauma, Neuroproteomics & Biomarker Research, McKnight Brain Institute, University of Florida, 1149 Newell Drive, Gainesville, FL 32610, USA.
Kevin K WangDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Joseph A TyndallDepartment of Emergency Medicine, University of Florida, 1329 SW 16 Street, Gainesville, FL 32608, USA.
Florida Cardiac Arrest Resource Team

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

objectivesTo assess ultra-early neuroprognostic significance of GFAP, NF-L, UCH-L1, tau, and S100B concentrations, change trajectory, and combination profile after Out-of-Hospital Cardiac Arrest (OHCA).

methodsProspective enrollment of 22 OHCA and 10 control patients at an academic tertiary care center between May 1, 2017 and January 28, 2020. Blood was collected within one hour of return of spontaneous circulation (ROSC) (H0), at hours 6 (H6), 12, 18, 24, and daily or until discharge or death. Biomarker concentrations, multifactor score, and trajectory change were assessed and compared to final neurologic status (good vs poor Cerebral Performance Category; CPC 1-2 vs CPC 3-5, respectively).

results10 patients had good and 12 had poor neurologic outcomes. Poor outcome patients had higher biomarker concentrations and combined biomarker scores at early time points. The earliest significant difference between good and poor outcome patients' serum biomarkers were at H12 for GFAP (good median: 425 pg/mL [IQR:370-630] vs poor: 5954[1712-65,055] pg/mL; p < 0.001), H12 for NF-L (64[41-69] vs 898[348-1990] pg/mL; p < 0.001), H0 for Tau (31[8-51] vs 124[53-238] pg/mL; p = 0.025), H0 for UCH-L1 (898[375-1600] vs 2475[1898-4098] pg/mL; p = 0.008), and H6 for S100B (123[70-290] vs 895[360-1199] pg/mL; p = 0.002). Four biomarker composite scores differed by H12 (78.03[52.03-111.25] vs 749 [198.46-4870.63] pg/mL; p = 0.003). Machine-learning approach also identified that four-marker score trajectory group memberships are in concordance with patient outcome.

conclusionsUltra-early serial serum concentrations of neuronal and astroglial biomarkers may be of neuroprognostic significance following OHCA.

Indexed as

BiomarkerCerebral performance categoryHypoxic-ischemic injuryNeurological outcomeNeuroprognosticationOut-of-hospital cardiac arrest

Identifiers

PMID34223394
PMCPMC8244405

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.