Evidence map›Paper›PMID 34223357›Full record

ArticleResuscitation plus2021

A hypothetical implementation of 'Termination of Resuscitation' protocol for out-of-hospital cardiac arrest.

Nuraini Nazeha, Marcus Eng Hock Ong, Alexander T Limkakeng, Jinny J Ye, Anjni Patel Joiner, Audrey Blewer, Nur Shahidah, Gayathri Devi Nadarajan, Desmond Renhao Mao, Nicholas Graves

Abstract read
In one paragraph

Article in Resuscitation plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nuraini NazehaHealth Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Marcus Eng Hock OngHealth Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Alexander T LimkakengDivision of Emergency Medicine, Duke University Hospital, Durham, NC, United States.
Jinny J YeDepartment of Emergency Medicine, Durham Veterans Affairs Medical Center, Durham, NC, United States.
Anjni Patel JoinerDivision of Emergency Medicine, Duke University Hospital, Durham, NC, United States.
Audrey BlewerDepartment of Family Medicine and Community Health and Department of Population Health Sciences, Duke University School of Medicine, NC, United States.
Nur ShahidahDepartment of Emergency Medicine, Singapore General Hospital, Singapore, Singapore.
Gayathri Devi NadarajanDepartment of Emergency Medicine, Singapore General Hospital, Singapore, Singapore.
Desmond Renhao MaoDepartment of Acute and Emergency Care, Khoo Teck Puat Hospital, Singapore, Singapore.
Nicholas GravesHealth Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOut-of-hospital cardiac arrests with negligible chance of survival are routinely transported to hospital and many are pronounced dead thereafter. This leads to some potentially avoidable costs. The 'Termination of Resuscitation' protocol allows paramedics to terminate resuscitation efforts onsite for medically futile cases. This study estimates the changes in frequency of costly events that might occur when the protocol is applied to out-of-hospital cardiac arrests, as compared to existing practice.

methodsWe used Singapore data from the Pan-Asian Resuscitation Outcomes Study, from 1 Jan 2014 to 31 Dec 2017. A Markov model was developed to summarise the events that would occur in two scenarios, existing practice and the implementation of a Termination of Resuscitation protocol. The model was evaluated for 10,000 hypothetical patients with a cycle duration of 30 days after having a cardiac arrest. Probabilistic sensitivity analysis accounted for uncertainties in the outcomes: number of urgent transports and emergency treatments, inpatient bed days, and total number of deaths.

resultsFor every 10,000 patients, existing practice resulted in 1118 (95% Uncertainty Interval 1117 to 1119) additional urgent transports to hospital and subsequent emergency treatments. There were 93 (95% Uncertainty Interval 66 to 120) extra inpatient bed days used, and 3 fewer deaths (95% Uncertainty Interval 2 to 4) in comparison to using the protocol.

conclusionThe findings provide some evidence for adopting the Termination of Resuscitation protocol. This policy could lead to a reduction in costs and non-beneficial hospital admissions, however there may be a small increase in the number of avoidable deaths.

Indexed as

Emergency medical servicesMarkov modelOut-of-hospital cardiac arrestTermination of Resuscitation

Identifiers

PMID34223357
PMCPMC8244430

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.