ArticleF&S reports2021
Novel ploidy analysis in ectopic pregnancy.
Article in F&S reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Does the type of gonadotropin used in the index IVF cycle affect subsequent frozen embryo transfer outcomes? Results of a retrospective analysis.Journal of assisted reproduction and genetics · 2026Article
- Assessing the risk of ectopic pregnancy following euploid frozen embryo transfer: a retrospective cohort study.Journal of assisted reproduction and genetics · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo study whether a single-nucleotide polymorphism (SNP) array could be used to test tissue from ectopic pregnancy to distinguish whether ectopic pregnancies were aneuploid.
designCase series report.
settingAcademic medical center. PATIENTS: One hundred seventy-eight women who underwent surgery for ectopic pregnancy at Northwestern Memorial Hospital between 2015 and 2018 were eligible for participation; written consent was obtained from 33 patients. Eight subjects had sufficient DNA samples and were included in the analysis. Maternal and paternal DNA samples were self-collected by buccal swab. Archived paraffin tissue containing chorionic villi from each surgically removed ectopic specimen was analyzed using SNP microarray technology to determine chromosome number and evaluate for maternal cell contamination.
interventionsNone.
main outcome measuresPrevalence of aneuploidy in ectopic pregnancy specimens as well as success of SNP array technology in formalin-fixed and paraffin-embedded specimens.
resultsSubjects had a mean (±SD) age of 33.4 ± 5.4 years, body mass index of 23.4 ± 5.7 kg/m
conclusionsThis study showed proof of concept for the use of routinely stored formalin-fixed, paraffin-embedded tissue blocks with DNA extraction for SNP array to detect ploidy status of ectopic pregnancy. Although all tested samples were euploid, further research is needed to gain a definitive answer to this question and better understand the mechanism that leads to ectopic implantation.
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Registered trials
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