ArticleF&S reports2020
Blastocyst score, a blastocyst quality ranking tool, is a predictor of blastocyst ploidy and implantation potential.
Article in F&S reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Trial emulation for validating the clinical efficacy of a foundational AI model in embryo selection.NPJ digital medicine · 2026Article
- Introducing the Blastocyst Fragmentation Indicator (BFI): A Novel Time-Lapse Metric for Enhanced Aneuploidy Risk Stratification in Non-Invasive Embryo Assessment.JBRA assisted reproduction · 2026Article
- Pregnancy and neonatal outcomes of borderline blastocysts: a novel evaluation model based on inner cell mass and trophectoderm parameters.Archives of gynecology and obstetrics · 2025Article
- A foundational model for in vitro fertilization trained on 18 million time-lapse images.Nature communications · 2025Article
- The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.Human reproduction (Oxford, England) · 2025Article
- Morphometric Blastocyst Assessment: A Retrospective Study Examining the Relationship Between Blastocyst Diameter and Area and Pregnancy Outcomes in Assisted Reproduction Technology Cycles.Journal of clinical medicine · 2025Article
- Combined Input Deep Learning Pipeline for Embryo Selection for In Vitro Fertilization Using Light Microscopic Images and Additional Features.Journal of imaging · 2025Article
- The integration of artificial intelligence in assisted reproduction: a comprehensive review.Frontiers in reproductive health · 2025Review
- Review
- Quantitative Standardized Expansion Assay: An Artificial Intelligence-Powered Morphometric Description of Blastocyst Expansion and Zona Thinning Dynamics.Life (Basel, Switzerland) · 2024Article
- Determining Factors Influencing The Successful Embryo Transfer and Pregnancy during The Frozen Cycle ofInternational journal of fertility & sterility · 2024Article
- Non-invasively predicting euploidy in human blastocysts via quantitative 3D morphology measurement: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2024Article
- Delayed Blastocyst Formation Reduces the Quality and Hatching Ability of Porcine Parthenogenetic Blastocysts by Increasing DNA Damage, Decreasing Cell Proliferation, and Altering Transcription Factor Expression Patterns.Journal of developmental biology · 2024Article
- Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging.Nature communications · 2024Article
- The impact of low oocyte maturity ratio on blastocyst euploidy rate: a matched retrospective cohort study.Contraception and reproductive medicine · 2024Article
- Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome.Journal of clinical medicine · 2024Article
- The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study.Journal of clinical medicine · 2024Article
- Can a sperm selection technique improve embryo ploidy?Andrology · 2023Article
- The correlation between morphological parameters and the incidence of de novo chromosomal abnormalities in 3238 biopsied blastocysts.Journal of assisted reproduction and genetics · 2023Article
- Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo convert blastocyst (BL) morphological grade and BL day into a numeric blastocyst score (BS).
designRetrospective cohort study.
settingAcademic center. PATIENTS: A total of 5,653 BL of known implantation (fetal heart, FH) and 11,348 biopsied BL.
interventionsBased on their FH rates and/or significance, a score (1-4) was assigned to each BL grade component. The BL morphological score (BMS) is the sum (BS = BMS on day 5; BS = BMS + 2 on day 6).
main outcome measuresStatistics characterized the FH and euploidy odds with BS.
resultsAll three morphology grade components and BL day were associated with implantation and euploidy probability. The FH rate and euploidy odds decrease with larger BS. The BS was the most important factor (odds ratio [OR] per unit change = 0.807, 95% confidence interval [CI] 0.784, 0.831) for untested and euploid BL implantation, and the sole one for euploid BL (OR/unit change = 0.845, 95% CI 0.803, 0.889). The BS is the second most significant factor after maternal age for euploidy probability (OR/unit change = 0.808, 95% CI 0.795, 0.822). In training and validation sets (75:25), the BS can predict implantation with similar area under the curve [AUC] (training = 0.628, 95% CI 0.613, 0.643; validation = 0.606, 95% CI 0.581, 0.631). The BS has better euploidy prediction ability (training AUC = 0.683, 95% CI 0.673, 0.693; validation AUC = 0.698, 95% CI 0.681, 0.715). The BS can stratify BL into good (3-5), fair (6-9), and poor (10-14) groups, reflecting their FH, live birth rates, and ploidy status. Advanced maternal age was associated with lower untested BL implantation and lower euploidy odds across all groups.
conclusionsThe BS is a predictor of BL ploidy and FH implantation.
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