ArticleF&S reports2020
Evidence of profound ovarian suppression on combined hormonal contraception resulting in dramatically different ovarian reserve testing and oocyte retrieval outcomes: case report and review of the literature.
Article in F&S reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Hyperresponse during ovarian stimulation despite profoundly suppressed ovarian reserve markers in a patient with long-term combined hormonal contraceptive use.F&S reports · 2025Article
- Potential biomarkers to predict return to fertility after discontinuation of female contraceptives-looking to the future.Frontiers in reproductive health · 2023Review
- Case for combined hormonal contraception holiday in fertility preservation patients.F&S reports · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveTo describe a case report and demonstrate that degree of ovarian suppression with continuous combined hormonal contraception (CHC) may be more profound than previously described and may present similarly as decreased ovarian reserve.
designCase report and review of the literature.
settingPrivate practice in vitro fertilization center. PATIENTS: A 36-year-old single gravida 0 presenting for oocyte cryopreservation on CHC.
interventionsDiscontinuation of vaginal ring combined hormonal contraceptive for 6 months.
main outcome measuresAntral follicle count, antimüllerian hormone, day 3 follicle-stimulating hormone, total oocytes, and mature oocytes retrieved before and after discontinuation of CHC.
resultsAfter a 6-month break from CHC, our patient's antimüllerian hormone level increased from undetectable levels to 3.45 ng/mL, day 3 follicle-stimulating hormone level decreased from 14.9 IU/mL-6.17 IU/mL, and antral follicle count improved from 0-28. In addition, the number of oocytes retrieved after a 4-month CHC break and 6-month break increased from 8 to 29, respectively.
conclusionsIn patients on long-term combined continuous hormonal contraception, profound ovarian suppression can result in a clinical picture of diminished ovarian reserve and extremely poor response to high-dose stimulation, which may be reversed by more time off from suppression.
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