Evidence map›Paper›PMID 34223221›Full record

ArticleF&S reports2020

Embryo cryopreservation and utilization in the United States from 2004-2013.

Mindy S Christianson, Judy E Stern, Fangbai Sun, Heping Zhang, Aaron K Styer, Wendy Vitek, Alex J Polotsky

Abstract read
In one paragraph

Article in F&S reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  6. One size does not fit all: the personal nature of completed embryo donation.Journal of assisted reproduction and genetics · 2024
    Article
  7. Too many embryos: a critical perspective on a global challenge.Journal of assisted reproduction and genetics · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mindy S ChristiansonDivision of Reproductive Endocrinology, Johns Hopkins University School of Medicine, Lutherville, Maryland.
Judy E SternObstetrics and Gynecology, Dartmouth-Hitchcock, Lebanon, New Hampshire.
Fangbai SunCollaborative Center for Statistics in Science, Yale School of Public Health, New Haven, Connecticut.
Heping ZhangCollaborative Center for Statistics in Science, Yale School of Public Health, New Haven, Connecticut.
Aaron K StyerColorado Center for Reproductive Medicine (CCRM) Fertility Clinic, Boston, Massachusetts.
Wendy VitekUniversity of Rochester School of Medicine and Dentistry, Rochester, New York.
Alex J PolotskyObstetrics and Gynecology, University of Colorado Denver, Denver, Colorado.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Clinical Research/Reproductive Scientist Training Program (CREST)R25HD075737 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Nanette F. Santoro · 2013 to 2026
$2.3M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS R25 HD075737
6 · The paper itself

Abstract

objectiveTo evaluate the quantity and use of embryos cryopreserved at assisted reproductive technology (ART) clinics in the United States from 2004 through 2013 and to characterize trends in ART cycles in which all embryos were cryopreserved.

designRetrospective analysis.

settingNot applicable. PATIENTS: Registry data from the Society for Assisted Reproductive Technology.

interventionsHistorical cohort of U.S. ART cycles reported to the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System between 2004 and 2013.

main outcome measuresNumber of embryos cryopreserved and factors associated with having cryopreserved embryos.

resultsThe percentage of fresh cycles in which all embryos were frozen increased dramatically each year after 2010: 15.6% (2010), 19.9% (2011), 30.7% (2012), and 40.7% (2013). During 10 years, 1,954,548 embryos were cryopreserved and 717,345 embryos were transferred. In freeze-only cycles from 2004 to 2013, there was a significant increase in the percentage of women with diminished ovarian reserve (19.9% to 34.1%) and in those who used preimplantation genetic testing (3.2% to 6.9%). During the 10-year period, there were 294,575 fresh cycles with embryo transfer and at least one embryo cryopreserved. Overall, 52.5% (n = 154,543) did not undergo a subsequent frozen embryo transfer, 29.5% (n = 40,462) were left with no frozen embryos, 50.4% (n = 68,875) had one-five embryos, and 20.0% (n = 27,396) had ≥six. Factors associated with having excess embryos included donor oocyte cycles and increased antimüllerian hormone levels.

conclusionsThere has been a sharp increase in U.S. ART cycles in which all embryos are frozen and this may result in more embryos in storage.

Indexed as

Embryo cryopreservationembryo dispositionin vitro fertilization

Identifiers

PMID34223221
PMCPMC8244341

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.