Evidence map›Paper›PMID 34223209›Full record

ArticleF&S reports2020

Tobacco consumption is associated with slow-growing day-6 blastocysts.

Mathilde Bourdon, Lucile Ferreux, Chloé Maignien, Catherine Patrat, Louis Marcellin, Khaled Pocate-Cheriet, Charles Chapron, Pietro Santulli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in F&S reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. IVF/ICSI Outcomes After a Freeze-All Strategy: an Observational Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Observational
  2. Reprotoxic Impact of Environment, Diet, and Behavior.International journal of environmental research and public health · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mathilde BourdonService de Gynécologie-Obstétrique II et de Médecine de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris.
Lucile FerreuxService d'Histologie-Embryologie-Biologie de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris, France.
Chloé MaignienService de Gynécologie-Obstétrique II et de Médecine de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris.
Catherine PatratService d'Histologie-Embryologie-Biologie de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris, France.
Louis MarcellinService de Gynécologie-Obstétrique II et de Médecine de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris.
Khaled Pocate-CherietService d'Histologie-Embryologie-Biologie de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris, France.
Charles ChapronService de Gynécologie-Obstétrique II et de Médecine de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris.
Pietro SantulliService de Gynécologie-Obstétrique II et de Médecine de la Reproduction, Faculté de Médecine, Sorbonne Paris Cité, Université de Paris, Assistance Publique-Hôpitaux de Paris Centre, Cochin, Paris.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate if there are any obvious clinical factors associated with delayed blastulation at day 6 (D6) compared with day 5 (D5).

designMonocentric observational cohort study from November 2012 to December 2018.

settingTertiary-care academic medical center. PATIENTS: A total of 941 women with an entire cohort of exclusively D5 blastocysts compared with 162 patients with a cohort of exclusively D6 blastocysts.

interventionsNone.

main outcome measuresClinical characteristics and data related to the ovarian stimulation protocols.

resultsAfter univariate analysis, a significantly higher proportion of women who were active smokers was found in the D6 group compared with the D5 group (n = 22/162 [13.6%] vs. n = 82/941 [8.7%]). In addition, the women in the D6 group had a higher rank number of assisted reproductive technology (ART; total no. of ART cycles performed: 2.1 ± 1.4 vs. 1.6 ± 1.1) and a lower antral follicle count (AFC; 18.7 ± 11.3 vs. 22.2 ± 12.8). Moreover, fertilization with the use of intracytoplasmic sperm injection was used more frequently in the D6 group compared with the D5 group. Logistic regression analysis adjusted for confounders highlighted several independent predictors for reaching blastocyst stage at D6 rather than D5: being an active smoker, previous ART cycles, and a lower AFC.

conclusionsObtaining an exclusively D6 blastocyst cohort is independently associated with women who are active smokers, previous ART cycles, and a lower AFC. These findings provide evidence, to be confirmed by further studies, that women who are active smokers could greatly benefit from smoking cessation before undergoing ART.

Indexed as

Assisted reproductive technologyblastocystday 5day 6

Identifiers

PMID34223209
PMCPMC8244283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.