ArticleSTAR protocols2021
Protocol for cryoinjury model in neonatal mice for heart regeneration and repair research.
Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Homovanillic acid improves anxiety by regulating F4/80+ microglia/macrophage in adult mice with neonatal cardiac injury.Scientific reports · 2026Article
- Effects of transcutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory on the skeletal muscle repair and gut microbiota modulation in rats with gastrocnemius muscle injury.Frontiers in rehabilitation sciences · 2026Article
- Protocol for tyramide signal amplification immunohistochemical detection of Notch1 signaling in the vascular system.STAR protocols · 2024Article
- The regenerative capacity of neonatal tissues.Development (Cambridge, England) · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The variability of animal experimental groups and high maternal cannibalization are two major limitations in cardiac injury models. A cryoinjury model could be an ideal model in heart regeneration and repair research as it can provide reproducible results and the injury size can be scaled. Here, we describe a simple and successful cryoinjury model (rate of mouse survival >90% and rate of maternal cannibalization <5%) for evaluating heart injury in regenerating and non-regenerating mice. For complete details on the use and execution of this protocol, please refer to Zhao et al. (2021).
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Registered trials
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