Evidence map›Paper›PMID 34223165›Full record

ArticleRSC medicinal chemistry2021

Studies on the affinity of 6-[(

Winnie Deuther-Conrad, Daniel Diez-Iriepa, Isabel Iriepa, Francisco López-Muñoz, María Angeles Martínez-Grau, Michael Gütschow, José Marco-Contelles

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 7 countries.

Winnie Deuther-ConradHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals 04318 Leipzig Germany w.deuther-conrad@hzdr.de.ORCID https://orcid.org/0000-0003-3168-3062
Daniel Diez-IriepaDepartment of Organic and Inorganic Chemistry, University of Alcalá Ctra. Madrid-Barcelona, Km. 33,6, 28871 Alcalá de Henares Madrid Spain.
Isabel IriepaDepartment of Organic and Inorganic Chemistry, University of Alcalá Ctra. Madrid-Barcelona, Km. 33,6, 28871 Alcalá de Henares Madrid Spain.ORCID https://orcid.org/0000-0003-3475-9624
Francisco López-MuñozFaculty of Health, Camilo José Cela University of Madrid (UCJC), Spain; Neuropsychopharmacology Unit, "Hospital 12 de Octubre" Research Institute Madrid Spain.
María Angeles Martínez-GrauMG Drug Discovery Consulting C/Nuria 28 2F 28034 Madrid Spain.
Michael GütschowPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn An der Immenburg 4 53121 Bonn Germany guetschow@uni-bonn.de.ORCID https://orcid.org/0000-0002-9376-7897
José Marco-ContellesLaboratory of Medicinal Chemistry, IQOG, CSIC C/Juan de la Cierva 3 28006 Madrid Spain jlmarco@iqog.csic.es.ORCID https://orcid.org/0000-0003-0690-0328
Universidad de Alcalá · ESDrug Discovery Laboratory (Norway) · NOHelmholtz-Zentrum Dresden-Rossendorf · DEIQ Samhällsbyggnad · SEResearch Institute Hospital 12 de Octubre · ESUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sigma (σ) receptors represent attractive targets for the development of potential agents for the treatment of several disorders, including Alzheimer's disease and neuropathic pain. In the search for multitarget small molecules (MSMs) against such disorders, we have re-discovered chromenones as new affine σ

Identifiers

PMID34223165
PMCPMC8221265
OpenAlexW3165609432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.