Evidence map›Paper›PMID 34223138›Full record

ArticleJAC-antimicrobial resistance2021

Selective digestive decontamination with oral colistin plus gentamicin for persistent bacteraemia caused by non-carbapenemase-producing carbapenem-resistant

Maria Spencer-Sandino, Roberto Riquelme-Neira, William C Shropshire, An Q Dinh, Gerardo González-Rocha, Paulina González-Muñoz, Alejandra Vera-Leiva, Rafael Araos, Blake Hanson, Cesar A Arias and 1 more

Open access · goldAbstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Multispecies emergence of dualAntimicrobial agents and chemotherapy · 2025
    Article
  2. Article
  3. Gastrointestinal colonization by OXA-48-producing Enterobacterales: risk factors for persistent carriage.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Maria Spencer-SandinoGenomics and Resistance Microbes (GeRM) Lab, Facultad de Medicina CAS-UDD, Instituto de Ciencias e Innovación en Medicina (ICIM), Santiago, Chile.
Roberto Riquelme-NeiraGenomics and Resistance Microbes (GeRM) Lab, Facultad de Medicina CAS-UDD, Instituto de Ciencias e Innovación en Medicina (ICIM), Santiago, Chile.
William C ShropshireCenter for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, TX, USA.
An Q DinhCenter for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, TX, USA.ORCID https://orcid.org/0000-0002-2965-9269
Gerardo González-RochaMillennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile.
Paulina González-MuñozMillennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile.
Alejandra Vera-LeivaUniversidad de Concepción, Facultad de Ciencias Biológicas, Departamento de Microbiología, Laboratorio de Investigación en Agentes Antibacterianos, Concepción, Chile.
Rafael AraosGenomics and Resistance Microbes (GeRM) Lab, Facultad de Medicina CAS-UDD, Instituto de Ciencias e Innovación en Medicina (ICIM), Santiago, Chile.
Blake HansonCenter for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, TX, USA.ORCID https://orcid.org/0000-0003-2949-7818
Cesar A AriasCenter for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, TX, USA.
José M MunitaGenomics and Resistance Microbes (GeRM) Lab, Facultad de Medicina CAS-UDD, Instituto de Ciencias e Innovación en Medicina (ICIM), Santiago, Chile.
Millennium Initiative for Collaborative Research on Bacterial Resistance · CLThe University of Texas Health Science Center at Houston · USUniversity of Concepción · CLUniversidad El Bosque · CO

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SAVIDGE, TOR C. · 2020 to 2025
$12.0M
VENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
NIAID NIH HHS K24 AI121296NIAID NIH HHS P01 AI152999NIAID NIH HHS R01 AI134637NIAID NIH HHS R01 AI148342
6 · The paper itself

Abstract

backgroundCarbapenem-resistant

objectivesTo report the use of SDD as a useful strategy for managing recalcitrant CR PATIENTS AND

methodsWe present a neutropenic patient with a recalcitrant bloodstream infection with non-CP-CR

resultsAfter 11 days of SDD treatment with oral colistin and gentamicin, bacteraemia was successfully eradicated. Genomic analysis indicates a fully carbapenem-resistant phenotype evolved

conclusionsOur report highlights that SDD might be a useful strategy to manage CR

Identifiers

PMID34223138
PMCPMC8215431
OpenAlexW3173537100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.