Evidence map›Paper›PMID 34222875›Full record

ArticleBrain communications2021

Association of plasma P-tau181 with memory decline in non-demented adults.

Joseph Therriault, Andrea L Benedet, Tharick A Pascoal, Firoza Z Lussier, Cecile Tissot, Thomas K Karikari, Nicholas J Ashton, Mira Chamoun, Gleb Bezgin, Sulantha Mathotaarachchi and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Comparative analyses of Alzheimer's disease blood biomarkers and cognitive domains.medRxiv : the preprint server for health sciences · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Plasma phosphorylated tau181 outperforms [European journal of neurology · 2024
    Article
  12. Article
  13. Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Joseph TherriaultTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.ORCID https://orcid.org/0000-0002-7826-4781
Andrea L BenedetTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.
Tharick A PascoalTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.
Firoza Z LussierTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.
Cecile TissotTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.
Thomas K KarikariDepartment of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.ORCID https://orcid.org/0000-0003-1422-4358
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.
Mira ChamounTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.
Gleb BezginTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.ORCID https://orcid.org/0000-0002-1069-9201
Sulantha MathotaarachchiTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.
Serge GauthierDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Paramita Saha-ChaudhuriDepartment of Epidemiology and Biostatistics, McGill University, Montreal, Canada.ORCID https://orcid.org/0000-0003-1987-320X
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.ORCID https://orcid.org/0000-0003-3930-4354
Kaj BlennowDepartment of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, McGill University, Montreal, Canada.
Alzheimer’s Disease Neuroimaging Initiative
Montreal Neurological Institute and Hospital · CASahlgrenska University Hospital · SEKing's College London · GBMcGill University · CAUniversity of Vermont · US

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MICHAEL W WEINER · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

Alzheimer's disease is the leading cause of dementia worldwide and is characterized by a long preclinical phase in which amyloid-β and tau accumulate in the absence of cognitive decline.

Indexed as

Alzheimer’s diseasememorymild cognitive impairmentplasmatau

Identifiers

PMID34222875
PMCPMC8249102
OpenAlexW3166886117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.