Evidence map›Paper›PMID 34222867›Full record

ArticleBrain communications2021

Evaluating cognitive profiles of patients undergoing clinical amyloid-PET imaging.

Flavia Loreto, Stephen Gunning, Mara Golemme, Hilary Watt, Neva Patel, Zarni Win, Christopher Carswell, Richard J Perry, Paresh A Malhotra

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Flavia LoretoDepartment of Brain Sciences, Faculty of Medicine, Imperial College London, London W6 8RP, UK.ORCID https://orcid.org/0000-0003-4729-9727
Stephen GunningDepartment of Neuropsychology, Imperial College Healthcare NHS Trust, London W6 8RF, UK.
Mara GolemmeDepartment of Neurology, Imperial College Healthcare NHS Trust, London W6 8RF, UK.
Hilary WattDepartment of Primary Care and Public Health, Faculty of Medicine, Imperial College London, London W6 8RP, UK.
Neva PatelDepartment of Nuclear Medicine, Imperial College Healthcare NHS Trust, London W6 8RF, UK.
Zarni WinDepartment of Nuclear Medicine, Imperial College Healthcare NHS Trust, London W6 8RF, UK.
Christopher CarswellDepartment of Neurology, Imperial College Healthcare NHS Trust, London W6 8RF, UK.
Richard J PerryDepartment of Brain Sciences, Faculty of Medicine, Imperial College London, London W6 8RP, UK.
Paresh A MalhotraDepartment of Brain Sciences, Faculty of Medicine, Imperial College London, London W6 8RP, UK.ORCID https://orcid.org/0000-0002-1897-0780
Imperial College Healthcare NHS Trust · GBImperial College London · GB

Funding

Medical Research Council MR/T033371/1
6 · The paper itself

Abstract

Episodic memory impairment and brain amyloid-beta are two of the main hallmarks of Alzheimer's Disease. In the clinical setting, these are often evaluated through neuropsychological testing and amyloid PET imaging, respectively. The use of amyloid PET in clinical practice is only indicated in patients with substantial diagnostic uncertainty due to atypical clinical presentation, multiple comorbidities and/or early age of onset. The relationship between amyloid-beta and cognition has been previously investigated, but no study has examined how neuropsychological features relate to the presence of amyloid pathology in the clinical population that meets the appropriate use criteria for amyloid PET imaging. In this study, we evaluated a clinical cohort of patients (

Indexed as

Alzheimer’s diseaseamyloid PET imagingcognitive testingdementianeuropsychology

Identifiers

PMID34222867
PMCPMC8244634
OpenAlexW3139108104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.