Evidence map›Paper›PMID 34222571›Full record

ArticleGenes & diseases2022

Identification of cross-reactive CD8

Chao Hu, Meiying Shen, Xiaojian Han, Qian Chen, Luo Li, Siyin Chen, Jing Zhang, Fengxia Gao, Wang Wang, Yingming Wang and 10 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Impaired and restored CD8Frontiers in immunology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Review
  11. The molecular mechanisms of CD8Frontiers in immunology · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Chao HuDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Meiying ShenDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, PR China.
Xiaojian HanDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Qian ChenDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Luo LiDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Siyin ChenDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Jing ZhangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Fengxia GaoDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Wang WangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Yingming WangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Tingting LiDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Shenglong LiDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Jingjing HuangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Jianwei WangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Ju ZhuDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.
Dan ChenDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.
Qingchen WuDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.
Kun TaoDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Da PangDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, PR China.
Aishun JinDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, PR China.
Chongqing Medical University · CNFirst Affiliated Hospital of Chongqing Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the growing knowledge of T cell responses in COVID-19 patients, there is a lack of detailed characterizations for T cell-antigen interactions and T cell functions. Here, with a predicted peptide library from SARS-CoV-2 S and N proteins, we found that specific CD8

Indexed as

CD8+T cellHLA class ILung organoidSARS-CoV-2T cell epitopeTCR

Identifiers

PMID34222571
PMCPMC8240504
OpenAlexW3175941513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.