Evidence map›Paper›PMID 34222488›Full record

ArticleBioMed research international2021

The Effect of Controlled Diabetes and Hyperglycemia on Implant Placement with Simultaneous Horizontal Guided Bone Regeneration: A Clinical Retrospective Analysis.

Paolo De Angelis, Paolo Francesco Manicone, Giulio Gasparini, Ilaria De Filippis, Margherita Giorgia Liguori, Silvio De Angelis, Francesca Cannata, Antonio D'Addona

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07364890 (Platelet-Derived Growth Factors to Enhance Healing and Reduce Post-Extraction Complications in Smokers), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07364890 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Platelet-Derived Growth Factors to Enhance Healing and Reduce Post-Extraction Complications in Smokers

TypeinterventionalSponsorKing Abdulaziz UniversityRan2026 to 2026Enrolled12ConditionsSmoke ExposureArmsA- PRF
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Paolo De AngelisDepartment of Head and Neck, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0002-0310-0037
Paolo Francesco ManiconeDepartment of Head and Neck, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.
Giulio GaspariniDepartment of Head and Neck, Division of Oral and Maxillofacial Surgery, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0001-5091-5178
Ilaria De FilippisDepartment of Head and Neck, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.
Margherita Giorgia LiguoriDepartment of Head and Neck, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.
Silvio De AngelisAscoli Piceno, Italy.
Francesca CannataDepartment of Head and Neck, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.
Antonio D'AddonaDepartment of Head and Neck, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.
Università Cattolica del Sacro Cuore · ITIstituto per le Applicazioni del Calcolo Mauro Picone · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes represents a challenge in implant therapy because hyperglycemia may negatively affect bone regeneration, directly compromising clinical outcomes and increasing clinical failures. The aim of this retrospective study is to analyse the prognostic significance of HbA1c levels in patients undergoing implant placement associated with horizontal guided bone regeneration. Thirty-four patients were divided into 3 groups according to their HbA1c levels: nondiabetic normoglycemic patients (HbA1c < 5.7%), nondiabetic hyperglycemic patients (HbA1c < 6.5%), and controlled diabetic patients (HbA1c < 7%). Primary outcomes were dimensional changes in height (VDH) and width (DW) of the peri-implant defect. Secondary outcomes were evaluations of periodontal parameters of adjacent tooth sites, wound healing, marginal bone loss (MBL), and survival and success rates. At

Indexed as

AdultAgedAlveolar Bone LossBiometryBone and BonesBone RegenerationDental Implantation, EndosseousDiabetes ComplicationsDiabetes MellitusFemaleGlycated HemoglobinGuided Tissue Regeneration, PeriodontalHumansHyperglycemiaJawMaleGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID34222488
PMCPMC8219425
OpenAlexW3169924385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.