Evidence map›Paper›PMID 34222484›Full record

ReviewBioMed research international2021

The New Challenge for Heart Endocarditis: From Conventional Prosthesis to New Devices and Platforms for the Treatment of Structural Heart Disease.

Francesco Nappi, Adelaide Iervolino, Sanjeet Singh Avtaar Singh

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Host-Bacterium Interaction Mechanisms inInternational journal of molecular sciences · 2023
    Pooled it
  3. Metabolites · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Application of New Materials in Auditory Disease Treatment.Frontiers in cellular neuroscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Francesco NappiDepartment of Cardiac Surgery, Centre Cardiologique du Nord, 93200 Saint-Denis, France.ORCID https://orcid.org/0000-0002-9705-5360
Adelaide IervolinoDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy.ORCID https://orcid.org/0000-0002-3208-4689
Sanjeet Singh Avtaar SinghDepartment of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow, UK.ORCID https://orcid.org/0000-0003-4320-0734
Agostino Gemelli University Polyclinic · ITCentre Cardiologique du Nord · FRGolden Jubilee National Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infective endocarditis is a sinister condition with considerable morbidity and mortality. Its relevance in the current era is compounded by the increased use of implanted devices such as replacement valves or cardiac implantable electronic devices. These infections are caused by multiple different bacteria with different virulence, pathogenicity, and antimicrobial resistance. Unlike in native endocarditis, the presence of foreign tissue permits sustenance by inflammatory and thrombotic processes as the artificial surfaces promote inflammatory responses and hypercoagulability. Prevention of these infections has been suggested with the use of homografts in combination with antibiotics. Others have attempted to use "low fouling coats" with little clinical success thus far. The use of antibiotic prophylaxis plays a pivotal part in reducing the incidence of prosthesis-related endocarditis. This remains especially crucial with the increasing use of transcatheter heart valve therapies. The widespread use of cardiac implantable electronic devices such as permanent pacemakers, implantable cardioverter defibrillators, and cardiac resynchronization therapy devices has also heralded a noticeable increase in cases of infectious endocarditis affecting complex equipment which can be difficult to treat. Multimodality strategies are needed with input from surgeons and cardiologists to ensure treatment is both prompt and successful, tailored to the individual needs of the patients.

Indexed as

Heart Valve ProsthesisProsthesis DesignAnimalsBiocompatible MaterialsDefibrillators, ImplantableEndocarditisHeart DiseasesHeart ValvesHumansInflammationPacemaker, ArtificialProsthesis ImplantationProsthesis-Related InfectionsRisk FactorsSwineBiocompatible Materials

Identifiers

PMID34222484
PMCPMC8219429
OpenAlexW3170359994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.