Evidence map›Paper›PMID 34222479›Full record

ArticleBioMed research international2021

Caspase-1-Inhibitor AC-YVAD-CMK Inhibits Pyroptosis and Ameliorates Acute Kidney Injury in a Model of Sepsis.

Mei Yang, Jin-Tao Fang, Ni-Shang Zhang, Long-Jiang Qin, Yang-Yang Zhuang, Wei-Wei Wang, Hai-Ping Zhu, Yan-Jie Zhang, Peng Xia, Yan Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 40 citations in OpenAlex.

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  10. Intravascular hemolysis as a converging mechanism in hemolytic disorders.American journal of physiology. Heart and circulatory physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mei YangDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Jin-Tao FangTransplantation Centre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Ni-Shang ZhangWenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Long-Jiang QinMedical Engineering Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Yang-Yang ZhuangDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Wei-Wei WangDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Hai-Ping ZhuDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Yan-Jie ZhangDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Peng XiaTransplantation Centre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.
Yan ZhangTransplantation Centre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China 325015.ORCID https://orcid.org/0000-0001-7965-0425
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the protective effect of AC-YVAD-CMK on sepsis-induced acute kidney injury in mice and to explore its possible mechanisms primarily.

methodsEighteen male C57BL/6 mice were randomly divided into sham-operated group (Control), cecal ligation and puncture group (CLP), and CLP model treated with AC-YVAD-CMK group (AC-YVAD-CMK) (

resultsAC-YVAD-CMK treatment significantly alleviates sepsis-induced acute kidney injury, with decreased histological injury in renal tissues, suppresses the accumulation of neutrophils and macrophages in renal tissues, and decreased sCR and BUN level (

conclusionsWe demonstrated a marked renoprotective effect of caspase-1-inhibitor AC-YVAD-CMK in a rat model of sepsis by inhibition of pyroptosis.

Indexed as

Acute Kidney InjuryAmino Acid Chloromethyl KetonesAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBlood Urea NitrogenCaspase 1Caspase InhibitorsCD68 MoleculeCreatinineCytokinesInterleukin-18Interleukin-1betaInterleukin-6KidneyMacrophagesAmino Acid Chloromethyl KetonesAntigens, CDAntigens, Differentiation, MyelomonocyticCaspase 1Caspase InhibitorsCD68 MoleculeCD68 protein, mouseCreatinineCytokinesIL1B protein, mouseInterleukin-18Interleukin-1betaInterleukin-6N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone

Identifiers

PMID34222479
PMCPMC8213477
OpenAlexW3171446917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.