Evidence map›Paper›PMID 34222363›Full record

ArticleFrontiers in cardiovascular medicine2021

Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension.

Fotios Spyropoulos, Zoe Michael, Benjamin Finander, Sally Vitali, Kosmas Kosmas, Panagiotis Zymaris, Brian T Kalish, Stella Kourembanas, Helen Christou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. A Cross-Species and Sex-Specific Meta-Analysis of Transcriptomic Studies of Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2025
    Pooled it
  2. Article
  3. Review
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  7. Article
  8. Article
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  10. Review
  11. Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fotios SpyropoulosDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Zoe MichaelDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Benjamin FinanderDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, United States.
Sally VitaliHarvard Medical School, Boston, MA, United States.
Kosmas KosmasDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Panagiotis ZymarisDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Brian T KalishDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, United States.
Stella KourembanasDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Helen ChristouDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Boston Children's Hospital · USHarvard University · USBrigham and Women's Hospital · US

Funding

HYPOXIC RESPONSES OF VASCULAR SMOOTH MUSCLER01HL055454 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI KOUREMBANAS, STELLA · 1996 to 2018
$6.7M
Neonatal Research Training ProgramT32HD098061 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Stella Kourembanas, Martha C. Sola-Visner · 2019 to 2026
$4.0M
Vascular smooth muscle cell phenotypic switching in Pulmonary HypertensionR01HL116573 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHRISTOU, HELEN · 2014 to 2017
$1.7M
NHLBI NIH HHS R01 HL055454NHLBI NIH HHS R01 HL116573NICHD NIH HHS T32 HD098061
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

carbonic anhydrase inhibitorcardiac metabolismfatty acid oxidationright heart failureSugen 5416 hypoxia model

Identifiers

PMID34222363
PMCPMC8247952
OpenAlexW3176793705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.