ReviewFrontiers in cell and developmental biology2021
Anti-biofilm Approach in Infective Endocarditis Exposes New Treatment Strategies for Improved Outcome.
Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 65 citations in OpenAlex.
- Antifungal Therapy in Candida Infective Endocarditis: A Comparison of Echinocandins and Other Treatment Regimens in a Nationwide Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Biofilms in clinical infection: pathophysiology, diagnosis, and the evolving therapeutic landscape.Journal of clinical microbiology · 2026Review
- What makes them stick? A genetic analysis of biofilm formation of an infective endocarditis-causingFrontiers in cellular and infection microbiology · 2026Article
- Discovery of a new fibronectin-binding surface protein ofFrontiers in cellular and infection microbiology · 2026Article
- Hyperbaric Oxygen Treatment as a Novel Add-on in Selected Patients with Infective Endocarditis - A Safety and Feasibility Trial.Infection and drug resistance · 2026Article
- The atypical quorum sensing system of classicalJournal of bacteriology · 2025Review
- Neutrophil Extracellular Traps (NETs) in health and disease.Molecular biomedicine · 2025Review
- Immune system dynamics in response to Pseudomonas aeruginosa biofilms.NPJ biofilms and microbiomes · 2025Review
- Deciphering the Complex Relationships Between the Hemostasis System and Infective Endocarditis.Journal of clinical medicine · 2025Review
- Hyperbaric oxygen therapy for cardiovascular surgery.Medical gas research · 2025Review
- In vivo virulence ofJTCVS open · 2025Article
- Review
- The global burden of pediatric infective endocarditis (5-14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.Frontiers in cardiovascular medicine · 2025Article
- The emerging challenge ofClinical microbiology reviews · 2024Review
- Infective Endocarditis by Biofilm-Producing Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2024Review
- HUSM endocarditis team's approach to acute ruptured chordae tendineae in chronic rheumatic heart disease.Clinical case reports · 2024Article
- Medical Device-Associated Infections Caused by Biofilm-Forming Microbial Pathogens and Controlling Strategies.Antibiotics (Basel, Switzerland) · 2024Review
- Review
- C-terminal deletion of RelA protein is suggested as a possible cause of infective endocarditis recurrence withAntimicrobial agents and chemotherapy · 2024Article
- Divergent genetic landscapes drive lower levels of AmpC induction and stable de-repression inAntimicrobial agents and chemotherapy · 2024Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infective endocarditis (IE) is a life-threatening infective disease with increasing incidence worldwide. From early on, in the antibiotic era, it was recognized that high-dose and long-term antibiotic therapy was correlated to improved outcome. In addition, for several of the common microbial IE etiologies, the use of combination antibiotic therapy further improves outcome. IE vegetations on affected heart valves from patients and experimental animal models resemble biofilm infections. Besides the recalcitrant nature of IE, the microorganisms often present in an aggregated form, and gradients of bacterial activity in the vegetations can be observed. Even after appropriate antibiotic therapy, such microbial formations can often be identified in surgically removed, infected heart valves. Therefore, persistent or recurrent cases of IE, after apparent initial infection control, can be related to biofilm formation in the heart valve vegetations. On this background, the present review will describe potentially novel non-antibiotic, antimicrobial approaches in IE, with special focus on anti-thrombotic strategies and hyperbaric oxygen therapy targeting the biofilm formation of the infected heart valves caused by
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.