Evidence map›Paper›PMID 34222219›Full record

ArticleFrontiers in bioengineering and biotechnology2021

High-Efficient Production of Adipose-Derived Stem Cell (ADSC) Secretome Through Maturation Process and Its Non-scarring Wound Healing Applications.

Young-Hyeon An, Dae Hyun Kim, Eun Jung Lee, Dabin Lee, Mihn Jeong Park, Junghyeon Ko, Dong Wook Kim, Jiwan Koh, Hyun Sook Hong, Youngsook Son and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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  14. Sprayable TiMaterials today. Bio · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Young-Hyeon AnSchool of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, South Korea.
Dae Hyun KimSenior Science & Life, Inc., Seoul, South Korea.
Eun Jung LeeSenior Science & Life, Inc., Seoul, South Korea.
Dabin LeeDepartment of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Mihn Jeong ParkInterdisciplinary Program in Bioengineering, Seoul National University, Seoul, South Korea.
Junghyeon KoSchool of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, South Korea.
Dong Wook KimDepartment of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Jiwan KohSenior Science & Life, Inc., Seoul, South Korea.
Hyun Sook HongDepartment of Biomedical Science and Technology, Kyung Hee University, Seoul, South Korea.
Youngsook SonDepartment of Biomedical Science and Technology, Kyung Hee University, Seoul, South Korea.
Je-Yoel ChoDepartment of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Ji-Ung ParkDepartment of Plastic and Reconstructive Surgery, Seoul National University Boramae Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Sun-Dong KimSenior Science & Life, Inc., Seoul, South Korea.
Nathaniel S HwangSchool of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, South Korea.
Seoul National University · KRKyung Hee University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, the stem cell-derived secretome, which is the set of proteins expressed by stem cells and secreted into the extracellular space, has been demonstrated as a critical contributor for tissue repair. In this study, we have produced two sets of high concentration secretomes from adipose-derived mesenchymal stem cells (ADSCs) that contain bovine serum or free of exogenous molecules. Through proteomic analysis, we elucidated that proteins related to extracellular matrix organization and growth factor-related proteins are highly secreted by ADSCs. Additionally, the application of ADSC secretome to full skin defect showed accelerated wound closure, enhanced angiogenic response, and complete regeneration of epithelial gaps. Furthermore, the ADSC secretome was capable of reducing scar formation. Finally, we show high-dose injection of ADSC secretome

Indexed as

proteomic analysissecretomeskin regenerationstem cellstissue repair

Identifiers

PMID34222219
PMCPMC8242583
OpenAlexW3172640249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.