ArticleFrontiers in bioengineering and biotechnology2021
Cortical Thickness Adaptive Response to Mechanical Loading Depends on Periosteal Position and Varies Linearly With Loading Magnitude.
Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Methodological aspects ofJournal of musculoskeletal & neuronal interactions · 2023Pooled it
- Built for bulk: posture, microanatomy and soft tissue shaped gigantism in Sauropoda.Royal Society open science · 2026Article
- A 50-year perspective on the use and potential of artiodactyl calcanei in bone adaptation studies.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Investigation of Cranial Bone Changes Indicative of Increased Intracranial Pressure in Diverse Phenotypes of Craniosynostosis.Plastic and reconstructive surgery. Global open · 2025Article
- Cranial bone thickness and density anomalies quantified from CT images can identify chronic increased intracranial pressure.Neuroradiology · 2024Article
- The Biomechanics of Musculoskeletal Tissues during Activities of Daily Living: Dynamic Assessment Using Quantitative Transmission-Mode Ultrasound Techniques.Healthcare (Basel, Switzerland) · 2024Review
- Cortical and Trabecular Bone Modeling and Implications for Bone Functional Adaptation in the Mammalian Tibia.Bioengineering (Basel, Switzerland) · 2024Review
- Cortical bone adaptation response is region specific, but not peak load dependent: insights fromBiomechanics and modeling in mechanobiology · 2024Article
- A novel framework for elucidating the effect of mechanical loading on the geometry of ovariectomized mouse tibiae using principal component analysis.Frontiers in bioengineering and biotechnology · 2024Article
- The loading direction dramatically affects the mechanical properties of the mouse tibia.Frontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The aim of the current study was to quantify the local effect of mechanical loading on cortical bone formation response at the periosteal surface using previously obtained μCT data from a mouse tibia mechanical loading study. A novel image analysis algorithm was developed to quantify local cortical thickness changes (ΔCt.Th) along the periosteal surface due to different peak loads (0N ≤ F ≤ 12N) applied to right-neurectomised mature female C57BL/6 mice. Furthermore, beam analysis was performed to analyse the local strain distribution including regions of tensile, compressive, and low strain magnitudes. Student's paired
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.