Evidence map›Paper›PMID 34222086›Full record

ArticleJournal of diabetes and metabolic disorders2021

The effect of methylethylpiridinol addition to the therapy on the level of pigment epithelium-derived factor and oxidative status in patients with diabetic nephropathy: randomized controlled open-label clinical study.

Sergey Sergeevich Popov, Elena Igorevna Anufrieva, Evgenii Dmitrievich Kryl'skii, Konstantin Konstantinovich Shulgin, Aleksey Nikolaevich Verevkin, Tatyana Nikolaevna Popova, Aleksander Nikolaevich Pashkov

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In one paragraph

Article in Journal of diabetes and metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sergey Sergeevich PopovVoronezh State Medical University named after N.N. Burdenko, Studencheskaya Street 10, 394036 Voronezh, Russia.ORCID 0000-0002-4438-9201
Elena Igorevna AnufrievaVoronezh State Medical University named after N.N. Burdenko, Studencheskaya Street 10, 394036 Voronezh, Russia.
Evgenii Dmitrievich Kryl'skiiVoronezh State University, Universitetskaya sq. 1, 394018 Voronezh, Russia.ORCID 0000-0002-8855-5515
Konstantin Konstantinovich ShulginVoronezh State University, Universitetskaya sq. 1, 394018 Voronezh, Russia.ORCID 0000-0001-9234-8124
Aleksey Nikolaevich VerevkinVoronezh State University, Universitetskaya sq. 1, 394018 Voronezh, Russia.ORCID 0000-0002-7412-9988
Tatyana Nikolaevna PopovaVoronezh State University, Universitetskaya sq. 1, 394018 Voronezh, Russia.ORCID 0000-0002-9660-3054
Aleksander Nikolaevich PashkovVoronezh State Medical University named after N.N. Burdenko, Studencheskaya Street 10, 394036 Voronezh, Russia.ORCID 0000-0003-2454-0397
Voronezh State University · RUVoronezh State Medical Academy named after N.N. Burdenko · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe diabetic nephropathy is associated with oxidative stress and increases in pigment epithelium-derived factor (PEDF) level in the patient's blood. For the first time, authors investigated the effect of methylethylpiridinol addition to the therapy on oxidative status and pigment epithelium-derived factor concentrations, and examined the relationship between these indicators and clinical markers of pathology development.

methodsStudy design: open label randomized controlled trial study. Authors assessed the effect of methylethylpiridinol addition to the therapy vs basic treatment on antioxidant and NADPH-generating enzymes activity, glutathione's concentration and free radical-induced oxidation's intensity using a spectrophotometric method and iron-induced biochemiluminescence. The pigment epithelium-derived factor concentration in the serum was measured by enzyme-linked immunosorbent assay.

resultsPatients receiving combination therapy with methylethylpiridinol showed a more substantial increase in activity of glutathione peroxidase (Δ = 0.04 ± 0.11, p = 0.002), glutathione transferase (Δ = 0.12 ± 0.08, p < 0.001) and the concentration of reduced glutathione (Δ = 0.30 ± 0.17, p = 0.039). In addition, there was a significant decrease in PEDF level (Δ = -6.4 ± 5.4, p = 0.004). Correlation analysis showed a negative link between Δ postprandial glucose and Δ NADP-isocitrate dehydrogenase (-0.39, p = 0.033), Δ reduced glutathione and Δ postprandial glucose (-0.372, p = 0.043), Δ glutathione transferase and Δ PEDF (-0.37, p = 0.044).

conclusionsThe methylethylpiridinol addition to the therapy had a more potent stimulating effect on the patients' oxidative status in comparison with standard treatment, and reliably decreased pigment epithelium-derived factor level in patients' serum. The observed differences seem to be associated with the antioxidant activity of methylethylpiridinol which contributing to the mitigation of oxidative stress reducing at diabetes mellitus.

Indexed as

Antioxidant systemDiabetic nephropathyMethylethylpiridinolOxidative stressPigment epithelium-derived factor

Identifiers

PMID34222086
PMCPMC8212231
OpenAlexW3162635680

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.