ArticleJournal of diabetes and metabolic disorders2021
Analysis of genetic selection at insulin receptor substrate-2 gene loci.
Article in Journal of diabetes and metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 author at 1 institution in 2 countries.
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Abstract
purposeType 2 diabetes mellitus (T2DM) is highly heritable and exhibits significant variability in prevalence between different populations. Prevalence of T2DM is higher in Asian and African relative to European populations. During evolution, traditional feast-famine cycles likely led to significant natural selection impacting metabolic genes. Human adaptation to environmental changes (food supply, lifestyle, climate, and geography) likely influenced differential selection of T2DM-associated genes. Together, insulin receptor substrate-1 and -2 (
methodsData were sourced from the HapMap and 1000 Genomes projects, comprising four different populations with distinct ancestries: European, Yoruba, Han Chinese, and Japanese. A three-step method was applied to detect
resultsThe African population exhibited highly significant LRH findings (percentile >99.9,
conclusionThese findings indicate that genetic selection has occurred at the SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40200-021-00745-y.
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