Evidence map›Paper›PMID 34222045›Full record

ArticleFrontiers in cellular and infection microbiology2021

Isolation of Mutants With Reduced Susceptibility to Piperaquine From a Mutator of the Rodent Malaria Parasite

Mie Ikeda, Makoto Hirai, Shin-Ichiro Tachibana, Toshiyuki Mori, Toshihiro Mita

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Microbiology spectrum · 2025
    Article
  2. Deletion of theAntimicrobial agents and chemotherapy · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mie IkedaDepartment of Tropical Medicine and Parasitology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Makoto HiraiDepartment of Tropical Medicine and Parasitology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Shin-Ichiro TachibanaDepartment of Tropical Medicine and Parasitology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Toshiyuki MoriDepartment of Tropical Medicine and Parasitology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Toshihiro MitaDepartment of Tropical Medicine and Parasitology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Juntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elucidation of the mechanisms of drug resistance in malaria parasites is crucial for combatting the emergence and spread of resistant parasites, which can be achieved by tracing resistance-associated mutations and providing useful information for drug development. Previously, we produced a novel genetic tool, a

Indexed as

AntimalarialsMalariaMalaria, FalciparumParasitesAnimalsMicePiperazinesPlasmodium bergheiPlasmodium falciparumProtozoan ProteinsQuinolinesRodentiaAntimalarialspiperaquinePiperazinesProtozoan ProteinsQuinolinesCRTfitnessmutants with reduced PPQ susceptibility 2mutatorpiperaquine resistancePlasmodium berghei

Identifiers

PMID34222045
PMCPMC8242943
OpenAlexW3166239080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.