ReviewAnesthesiology and pain medicine2021
Utilization of Magnesium for the Treatment of Chronic Pain.
Review in Anesthesiology and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Intravenous Nalbuphine Versus Magnesium Sulfate on Emergence Agitation in Pediatric Patients Scheduled for Hypospadias Repair
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD: A Prospective Randomized Design
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Ketamine and other NMDA receptor antagonists for chronic pain.The Cochrane database of systematic reviews · 2025Pooled it
- Effects of intraoperative Magnesium sulfate infusion on emergency agitation during general anesthesia in patients undergoing radical mastectomy: a randomized controlled study.BMC anesthesiology · 2023Trial
- Article
- Intraoperative magnesium sulphate as an analgesic adjunct in a multimodal, opioid-sparing protocol for canine ovariohysterectomy: a prospective, randomized, controlled, double-blind study.Frontiers in veterinary science · 2026Article
- Magnesium sulfate in oxidative stress-associated pathologies: clinical, cellular, and molecular perspectives.Biophysical reviews · 2025Review
- Comparison of Perioperative Pregabalin and Duloxetine for Pain Management After Total Knee Arthroplasty: A Double-Blind Clinical Trial.Anesthesiology and pain medicine · 2023Article
- Pain Management in Older Adults with Chronic Wounds.Drugs & aging · 2022Review
- Current Strategies in Pain Regimens for Robotic Urologic Surgery: A Comprehensive Review.Anesthesiology and pain medicine · 2022Review
- Anesthetic Conversion of Preexisting Labor Epidural Analgesia for Emergency Cesarean Section and Efficacy of Levobupivacaine with or Without Magnesium Sulphate: A Prospective Randomized Study.Anesthesiology and pain medicine · 2022Article
- Novel Local Anesthetics in Clinical Practice: Pharmacologic Considerations and Potential Roles for the Future.Anesthesiology and pain medicine · 2022Review
- Evaluation of the Effects of Oral Magnesium Sachet on the Prevention of Spinal Anesthesia-Induced Headache After Cesarean Section: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2022Article
- The Effect of Pneumoperitoneum-induced Hypertension During Laparoscopic Cholecystectomy Under General Anesthesia on Postoperative Pain: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2021Article
- Comparison of Intraperitoneal Bupivacaine and Intravenous Ketorolac for Postoperative Pain Management Following Laparoscopic Cholecystectomy.Anesthesiology and pain medicine · 2021Article
- Mirogabalin as a Novel Gabapentinoid for the Treatment of Chronic Pain Conditions: An Analysis of Current Evidence.Anesthesiology and pain medicine · 2021Review
- Antibiotics for Spinal Cord Stimulation Trials and Implants: A Survey Analysis of Practice Patterns.Anesthesiology and pain medicine · 2021Article
- Pain Control After Mastectomy in Transgender Patients: Ultrasound-guided Pectoral Nerve Block II Versus Conventional Intercostal Nerve Block: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2021Article
- A Comprehensive Update of the Current Understanding of Chronic Fatigue Syndrome.Anesthesiology and pain medicine · 2021Review
- Efficacy of Acupuncture in the Treatment of Chronic Abdominal Pain.Anesthesiology and pain medicine · 2021Review
- Dorsal Root Ganglion (DRG) and Chronic Pain.Anesthesiology and pain medicine · 2021Review
- Efficacy of Dry Needling and Acupuncture in the Treatment of Neck Pain.Anesthesiology and pain medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. EVIDENCE ACQUISITION: Narrative review.
resultsThere are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction.
conclusionsThis narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.