Evidence map›Paper›PMID 34221864›Full record

ReviewActa pharmaceutica Sinica. B2021

Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses.

Qian Hu, Christopher J Lyon, Jesse K Fletcher, Wenfu Tang, Meihua Wan, Tony Y Hu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed.

  1. Article
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  11. Article
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  15. Enhanced Bioactivity ofFood science & nutrition · 2026
    Article
  16. Review
  17. Review
  18. Toxins · 2026
    Article
  19. Article
  20. Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qian HuDepartment of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Christopher J LyonCenter of Cellular and Molecular Diagnosis, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Jesse K FletcherCenter of Cellular and Molecular Diagnosis, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Wenfu TangDepartment of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Meihua WanDepartment of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Tony Y HuCenter of Cellular and Molecular Diagnosis, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages are typically identified as classically activated (M1) macrophages and alternatively activated (M2) macrophages, which respectively exhibit pro- and anti-inflammatory phenotypes, and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation, injury, and repair processes. Recent studies indicate that tissue cells and macrophages interact

Indexed as

ADSCs, adipose-derived stem cellsAKI, acute kidney injuryALI, acute lung injuryAMs, alveolar macrophagesBMSCs, bone marrow stromal cellsCLP, cecal ligation and punctureDSS, dextran sodium sulphateEVs, extracellular vesiclesExtracellular vesiclesHSPA12B, heat shock protein A12BHUCMSCs, human umbilical cord mesenchymal stem cellsIBD, inflammatory bowel diseaseICAM-1, intercellular adhesion molecule 1IL-1β, interleukin-1βInflammatory diseaseiNOS, inducible nitrogen oxide synthaseInteraction loopKCs, Kupffer cellsKLF4, krüppel-like factor 4LPS, lipopolysaccharidesMacrophageMHC, major histocompatibility complexMSCs, mesenchymal stromal cellsMVs, microvesiclesPEG, polyethylene glycolPMFA, 5,7,30,40,50-pentamethoxyflavanonePPARγ, peroxisome proliferator-activated receptor γSepsisSIRPα, signal regulatory protein αStem cellTargeted therapyTECs, tubular epithelial cellsTissue injuryTNF, tumor necrosis factorTRAIL, tumor necrosis factor-related apoptosis-inducing ligand

Identifiers

PMID34221864
PMCPMC8245807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.