Evidence map›Paper›PMID 34221805›Full record

Article3 Biotech2021

Preparation, characterization and its potential applications in Isoniazid drug delivery of porous microcrystalline cellulose from banana pseudostem fibers.

Meghna Diarsa, Akshaya Gupte

Open access · greenAbstract read
In one paragraph

Article in 3 Biotech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Meghna DiarsaDepartment of Microbiology, Natubhai V. Patel College of Pure and Applied Sciences, Vallabh Vidyanagar, Gujarat 388 120 India.
Akshaya GupteDepartment of Microbiology, Natubhai V. Patel College of Pure and Applied Sciences, Vallabh Vidyanagar, Gujarat 388 120 India.ORCID 0000-0002-9162-741X
Manubhai Patel Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Banana pseudostem, a cellulose-rich by-product, is regarded as an important agricultural waste during the process of banana production. Microcrystalline cellulose was successfully prepared from banana pseudostem using acid hydrolysis method. Microcrystalline cellulose was characterized through various techniques such as XRD, TGA, SEM, FTIR and antioxidant activity to explore the possible applications in the pharmaceutical industries especially as a drug delivery vehicle. The investigation revealed that the derived microcrystalline cellulose is non-aggregated, short rods with high crystallinity index 67% and stable up to 347 °C. FTIR spectroscopy showed that hydrolysis treatments are efficient for the removal of lignin and hemicellulose content. Microcrystalline cellulose exhibited good antioxidant activity 90.29% at 100 μg/ml. In vitro studies for the drug release were carried out in simulated intestinal fluid (SIF) using Isoniazid drug. The study proves that microcrystalline cellulose can be directly obtained from banana pseudostem which is not only beneficial to reduce the cost of traditional microcrystalline cellulose but is also conducive to the value-added utilization of the pseudostem.

Indexed as

Antioxidant activityBanana pseudostemDrug deliveryMicrocrystalline celluloseThermal stability

Identifiers

PMID34221805
PMCPMC8206307
OpenAlexW3168501244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.