ArticleBiomedical optics express2021
0.1 THz exposure affects primary hippocampus neuron gene expression via alternating transcription factor binding.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Non-Thermal Effects of Terahertz Radiation on Gene Expression: Systematic Review and Meta-Analysis.Genes · 2024Pooled it
- 3.75 THz Repetitive Radiation Regulates Collagen Metabolism in Human Fetal Scleral Fibroblasts.Cells · 2026Article
- Response of pheochromocytoma neuronal cells to varying intensity of continuous wave terahertz radiation.Journal of synchrotron radiation · 2025Article
- Article
- THz Waves Improve Spatial Working Memory by Increasing the Activity of Glutamatergic Neurons in Mice.Cells · 2025Article
- Membrane-mediated modulation of mitochondrial physiology by terahertz waves.Biomedical optics express · 2024Article
- Article
- Examining DNA breathing with pyDNA-EPBD.Bioinformatics (Oxford, England) · 2023Article
- The biological effects of terahertz wave radiation-induced injury on neural stem cells.iScience · 2023Article
- Article
- Continuous wave irradiation at 0.1 terahertz facilitates transmembrane transport of small molecules.iScience · 2022Article
- A Comparative Study on the Viability of Normal and Cancerous Cells upon Irradiation with a Steady Beam of THz Rays.Life (Basel, Switzerland) · 2022Article
- Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility.Research (Washington, D.C.) · 2022Article
- Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiationiScience · 2021Article
- Advances of terahertz technology in neuroscience: Current status and a future perspective.iScience · 2021Review
- Effects of high intensity non-ionizing terahertz radiation on human skin fibroblasts.Biomedical optics express · 2021Article
- Cellular effects of terahertz waves.Journal of biomedical optics · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, many studies have been conducted to investigate the influence of terahertz (THz) radiation on the gene expression in various cell types, but the underling molecular mechanism has not yet been fully revealed. In this study, we explored the effects of 0.1 THz radiation on the gene expression in primary neuron cells through RNA-seq analysis. 111 up-regulated and 54 down-regulated genes were identified. Several biomolecule binding related categories such as "long-chain fatty acid binding", "tropomyosin binding", "BMP receptor binding", as well as "GTPase binding" and "phospholipid binding" were enriched by GO analysis. Moreover, the GSEA analysis indicated that genes encoding protein biosynthetic machinery ribosome were up-regulated by 0.1 THz irradiation. In addition, we demonstrated that the binding efficiency of a transcription factor (TF) AP-1 with its transcription factor binding site (TFBS) in DNA was reduced by THz irradiation, which suggested that THz irradiation might affect the interaction between TFs with DNA and consequently regulate the gene expression. Our results provide new insights into the biological effects of terahertz irradiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.