ArticleBiomedical optics express2021
Large-scale, cell-resolution volumetric mapping allows layer-specific investigation of human brain cytoarchitecture.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- mViSE: A visual search engine for analyzing multiplex IHC brain tissue images (spatial proteomics).Scientific reports · 2026Article
- Myelinated fiber labeling and orientation mapping of the human brain with light-sheet fluorescence microscopy.NeuroImage · 2025Article
- Quantitative cytoarchitectural phenotyping of deparaffinized human brain tissues.Communications biology · 2025Article
- Anisotropic light propagation in human brain white matter.Neurophotonics · 2025Article
- Frontiers in artificial intelligence-directed light-sheet microscopy for uncovering biological phenomena and multi-organ imaging.View (Beijing, China) · 2024Article
- Deep learning-based localization algorithms on fluorescence human brain 3D reconstruction: a comparative study using stereology as a reference.Scientific reports · 2024Article
- A robust vessel-labeling pipeline with high tissue clearing compatibility for 3D mapping of vascular networks.iScience · 2024Article
- A complementary approach for neocortical cytoarchitecture inspection with cellular resolution imaging at whole brain scale.Frontiers in neuroanatomy · 2024Article
- A cellular resolution atlas of Broca's area.Science advances · 2023Article
- A Guide to Perform 3D Histology of Biological Tissues with Fluorescence Microscopy.International journal of molecular sciences · 2023Review
- Fiber enhancement and 3D orientation analysis in label-free two-photon fluorescence microscopy.Scientific reports · 2023Article
- Studying the trafficking of labeled trodusquemine and its application as nerve marker for light-sheet and expansion microscopy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- 3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy.Communications biology · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Exploring the human cerebral cortex using confocal microscopy.Progress in biophysics and molecular biology · 2022Article
- Editorial: The human brain multiscale imaging challenge.Frontiers in neuroanatomy · 2022Article
- β-Cell Pathophysiology: A Review of Advanced Optical Microscopy Applications.International journal of molecular sciences · 2021Review
- Large-scale, cell-resolution volumetric mapping allows layer-specific investigation of human brain cytoarchitecture.Biomedical optics express · 2021Article
- Comparison of Different Tissue Clearing Methods for Three-Dimensional Reconstruction of Human Brain Cellular Anatomy Using Advanced Imaging Techniques.Frontiers in neuroanatomy · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Although neuronal density analysis on human brain slices is available from stereological studies, data on the spatial distribution of neurons in 3D are still missing. Since the neuronal organization is very inhomogeneous in the cerebral cortex, it is critical to map all neurons in a given volume rather than relying on sparse sampling methods. To achieve this goal, we implement a new tissue transformation protocol to clear and label human brain tissues and we exploit the high-resolution optical sectioning of two-photon fluorescence microscopy to perform 3D mesoscopic reconstruction. We perform neuronal mapping of 100mm
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Registered trials
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