ArticleBiomedical optics express2021
Choosing a model for laser speckle contrast imaging.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Physics-informed neural network for mapping vascular and tissue dynamics using laser speckle contrast imaging.Neurophotonics · 2026Article
- Article
- Mapping fast tissue dynamics with long camera exposures via intensity modulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comparative validation of speckle contrast optical spectroscopy against diffuse correlation spectroscopy for monitoring human cerebral blood flow.Neurophotonics · 2026Article
- Cardiac pulse transfer along the cerebral microvascular network captured by laser speckle contrast imaging.Biomedical optics express · 2026Article
- Detection of non-invasive sexing of early chick embryos in intact eggs using laser speckle contrast imaging and deep neural networks.PloS one · 2026Article
- Assessing human scalp and brain blood flow sensitivities via superficial temporal artery occlusion using speckle contrast optical spectroscopy.APL bioengineering · 2025Article
- Noncontact diffuse optical imaging of blood flow and oxygenation distributions in reconstructive rat skin flaps.Biomedical optics express · 2025Article
- Mapping of blood flow and slow speckle tissue dynamics using laser speckle contrast imaging.Biomedical optics express · 2025Article
- Non-ergodicity and noise-corrected diffuse speckle contrast analysis in deep tissue blood flow measurement.Biomedical optics express · 2025Article
- Choice of numerical implementation of spatial contrast calculation impacts microcirculation quantitation in laser speckle contrast imaging.Journal of biomedical optics · 2025Article
- Laser speckle contrast imaging with principal component and entropy analysis: a novel approach for depth-independent blood flow assessment.Frontiers of optoelectronics · 2025Article
- Real-time monitoring of spinal cord hemodynamics with laser speckle contrast imaging during pedicle subtraction osteotomy in rabbits.Frontiers in surgery · 2025Article
- Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease.Neurophotonics · 2025Article
- Impact of light polarization on laser speckle contrast imaging with a custom phantom for microvascular flow.Scientific reports · 2024Article
- Dual-mode optical projection mapping system: integration of laser speckle contrast and subcutaneous vein imaging.Biomedical engineering letters · 2024Article
- Non-invasive laser speckle contrast imaging (LSCI) of extra-embryonic blood vessels in intact avian eggs at early developmental stages.Biomedical optics express · 2024Article
- Laser speckle imaging of the hippocampus.Biomedical optics express · 2024Article
- Dynamic light scattering and laser speckle contrast imaging of the brain: theory of the spatial and temporal statistics of speckle pattern evolution.Biomedical optics express · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laser speckle contrast imaging (LSCI) is a real-time full-field non-invasive technique, which is broadly applied to visualize blood flow in biomedical applications. In its foundation is the link between the speckle contrast and dynamics of light scattering particles-erythrocytes. The mathematical form describing this relationship, which is critical for accurate blood flow estimation, depends on the sample's light-scattering properties. However, in biological applications, these properties are often unknown, thus requiring assumptions to be made to perform LSCI analysis. Here, we review the most critical assumptions in the LSCI theory and simulate how they affect blood flow estimation accuracy. We show that the most commonly applied model can severely underestimate the flow change, particularly when imaging brain parenchyma or other capillary perfused tissue (e.g. skin) under ischemic conditions. Based on these observations and guided by the recent experimental results, we propose an alternative model that allows measuring blood flow changes with higher accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.