Evidence map›Paper›PMID 34221678›Full record

ArticleBiomedical optics express2021

High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source.

Shuibin Ni, Xiang Wei, Ringo Ng, Susan Ostmo, Michael F Chiang, David Huang, Yali Jia, J Peter Campbell, Yifan Jian

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 75 citations in OpenAlex.

  1. Utility of handheld optical coherence tomography imaging in the surgical management of preterm infants with advanced retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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  6. Widefield OCT angiography.Progress in retinal and eye research · 2025
    Review
  7. Mobile Robotic Optical Coherence Tomography System for Ophthalmic Imaging in Clinical Environments.... International Symposium on Medical Robotics. International Symposium on Medical Robotics · 2025
    Article
  8. Advances in OCT Angiography.Translational vision science & technology · 2025
    Review
  9. New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.Translational vision science & technology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Optical Assessment of Photoreceptor Function Over the Macula.Translational vision science & technology · 2024
    Article
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  19. Panretinal Optical Coherence Tomography.IEEE transactions on medical imaging · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shuibin NiCasey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Xiang WeiCasey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.ORCID https://orcid.org/0000-0002-4794-6018
Ringo NgDepartment of Engineering Science, Simon Fraser University, Burnaby, Canada.
Susan OstmoCasey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Michael F ChiangNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
David HuangCasey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Yali JiaCasey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.ORCID https://orcid.org/0000-0002-2784-1905
J Peter CampbellCasey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Yifan JianCasey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.
National Institutes of Health · USSimon Fraser University · CA

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
Clinical and Genetic Analysis of Retinopathy of PrematurityR01EY019474 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER · 2010 to 2020
$7.0M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
Artificial Intelligence Assisted Panoramic Optical Coherence Tomography Angiography for Retinopathy of PrematurityR01HD107494 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell, Yifan Jian · 2021 to 2026
$2.4M
Clinical and genetic analysis of retinopathy of prematurityR01HD107493 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER · 2021 to 2023
$1.8M
Wide-field and projection-resolved optical coherence tomography angiography in diabetic retinopathyR01EY027833 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HWANG, THOMAS, JIA, YALI · 2017 to 2020
$1.8M
Artificial intelligence assisted panoramic Optical Coherence Tomography Angiography for Retinopathy of PrematurityR01EY031331 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER, JIAN, YIFAN · 2020 to 2020
$342k
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY019474NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY027833NEI NIH HHS R01 EY031331NICHD NIH HHS R01 HD107493NICHD NIH HHS R01 HD107494
6 · The paper itself

Abstract

Optical coherence tomography (OCT) and OCT angiography (OCTA) enable noninvasive structural and angiographic imaging of the eye. Portable handheld OCT/OCTA systems are required for imaging patients in the supine position. Examples include infants in the neonatal intensive care unit (NICU) and operating room (OR). The speed of image acquisition plays a pivotal role in acquiring high-quality OCT/OCTA images, particularly with the handheld system, since both the operator hand tremor and subject motion can cause significant motion artifacts. In addition, having a large field of view and the ability of real-time data visualization are critical elements in rapid disease screening, reducing imaging time, and detecting peripheral retinal pathologies. The arrangement of optical components is less flexible in the handheld system due to the limitation of size and weight. In this paper, we introduce a 400-kHz, 55-degree field of view handheld OCT/OCTA system that has overcome many technical challenges as a portable OCT system as well as a high-speed OCTA system. We demonstrate imaging premature infants with retinopathy of prematurity (ROP) in the NICU, a patient with incontinentia pigmenti (IP), and a patient with X-linked retinoschisis (XLRS) in the OR using our handheld OCT system. Our design may have the potential for improving the diagnosis of retinal diseases and help provide a practical guideline for designing a flexible and portable OCT system.

Identifiers

PMID34221678
PMCPMC8221946
OpenAlexW3154464020

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.