Evidence map›Paper›PMID 34221491›Full record

ArticleJournal of ophthalmology2021

Combined Low-Level Light Therapy and Intense Pulsed Light Therapy for the Treatment of Dry Eye in Patients with Sjögren's Syndrome.

Matteo Di Marino, Paola Conigliaro, Francesco Aiello, Claudia Valeri, Clarissa Giannini, Raffaele Mancino, Stella Modica, Carlo Nucci, Roberto Perricone, Massimo Cesareo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  4. Observational
  5. Article
  6. Aesthetic Treatment Considerations in Patients with Cutaneous Autoimmune Disease.The Journal of clinical and aesthetic dermatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Matteo Di MarinoOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy.ORCID https://orcid.org/0000-0001-6926-9655
Paola ConigliaroRheumatology, Allergology and Clinical Immunology, Department of Medicina Dei Sistemi, University of Rome Tor Vergata, Rome 00133, Italy.
Francesco AielloOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy.ORCID https://orcid.org/0000-0001-6479-1807
Claudia ValeriOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy.
Clarissa GianniniOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy.
Raffaele MancinoOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy.
Stella ModicaRheumatology, Allergology and Clinical Immunology, Department of Medicina Dei Sistemi, University of Rome Tor Vergata, Rome 00133, Italy.
Carlo NucciOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy.
Roberto PerriconeRheumatology, Allergology and Clinical Immunology, Department of Medicina Dei Sistemi, University of Rome Tor Vergata, Rome 00133, Italy.
Massimo CesareoOphthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effects of combined intense pulsed light therapy (IPL) and low-level light therapy (LLLT) in dry eye disease (DED) in patients affected by Sjögren's syndrome.

resultsBUT test showed an increase in tear film breakup time in patients with DED 1 month after the beginning of the treatment (T0 vs T1:

conclusionsThe use of combined IPL/LLLT for the treatment of DED in patients affected by Sjögren's syndrome appears to be beneficial.

Identifiers

PMID34221491
PMCPMC8213457
OpenAlexW3169203763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.