Evidence map›Paper›PMID 34221389›Full record

ArticleClinical kidney journal2021

Scope and heterogeneity of outcomes reported in randomized trials in patients receiving peritoneal dialysis.

Karine E Manera, David W Johnson, Yeoungjee Cho, Benedicte Sautenet, Jenny Shen, Ayano Kelly, Angela Yee-Moon Wang, Edwina A Brown, Gillian Brunier, Jeffrey Perl and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Heart failure events in randomized controlled trials for adults receiving maintenance dialysis: a meta-epidemiologic study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Epidemiology of peritoneal dialysis outcomes.Nature reviews. Nephrology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 15 institutions in 9 countries.

Karine E ManeraSydney School of Public Health, University of Sydney, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-0552-6074
David W JohnsonDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Yeoungjee ChoDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Benedicte SautenetDepartment of Nephrology-Hypertension, Dialysis, Kidney Transplantation, Tours Hospital, Tours, France.
Jenny ShenDivision of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ayano KellyCentre for Kidney Research, Children's Hospital at Westmead, Sydney, NSW, Australia.
Angela Yee-Moon WangDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
Edwina A BrownImperial College Renal and Transplant Centre, Hammersmith Hospital, London, UK.
Gillian BrunierSunnybrook Research Institute, Toronto, ON, Canada.
Jeffrey PerlDivision of Nephrology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Jie DongRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Martin WilkieDepartment of Nephrology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Rajnish MehrotraDivision of Nephrology/Department of Medicine, Kidney Research Institute and Harborview Medical Center, University of Washington, Seattle, WA, USA.
Roberto Pecoits-FilhoSchool of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-0255-6710
Saraladevi NaickerDepartment of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tony DunningSouth Bank TAFE, Brisbane, QLD, Australia.
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Allison TongSydney School of Public Health, University of Sydney, Sydney, NSW, Australia.
The University of Queensland · AUThe University of Sydney · AUAustralian National University · AUFlinders University · AUHammersmith Hospital · GBInserm · FRPeking University · CNPontifícia Universidade Católica do Paraná · BRQueen Mary Hospital · CNSheffield Teaching Hospitals NHS Foundation Trust · GBSt. Michael's Hospital · CASunnybrook Hospital · CAThe Lundquist Institute · USUniversity of the Witwatersrand · ZAUniversity of Washington · US

Funding

Trajectories of Adherence to Cardiovascular Medications in Patients on DialysisK23DK103972 · NIDDK · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI SHEN, JENNY I · 2015 to 2019
$934k
NIDDK NIH HHS K23 DK103972
6 · The paper itself

Abstract

backgroundRandomized trials can provide evidence to inform decision-making but this may be limited if the outcomes of importance to patients and clinicians are omitted or reported inconsistently. We aimed to assess the scope and heterogeneity of outcomes reported in trials in peritoneal dialysis (PD).

methodsWe searched the Cochrane Kidney and Transplant Specialized Register for randomized trials in PD. We extracted all reported outcome domains and measurements and analyzed their frequency and characteristics.

resultsFrom 128 reports of 120 included trials, 80 different outcome domains were reported. Overall, 39 (49%) domains were surrogate, 23 (29%) patient-reported and 18 (22%) clinical. The five most commonly reported domains were PD-related infection [59 (49%) trials], dialysis solute clearance [51 (42%)], kidney function [45 (38%)], protein metabolism [44 (37%)] and inflammatory markers/oxidative stress [42 (35%)]. Quality of life was reported infrequently (4% of trials). Only 14 (12%) trials included a patient-reported outcome as a primary outcome. The median number of outcome measures (defined as a different measurement, aggregation and metric) was 22 (interquartile range 13-37) per trial. PD-related infection was the most frequently reported clinical outcome as well as the most frequently stated primary outcome. A total of 383 different measures for infection were used, with 66 used more than once.

conclusionsTrials in PD include important clinical outcomes such as infection, but these are measured and reported inconsistently. Patient-reported outcomes are infrequently reported and nearly half of the domains were surrogate. Standardized outcomes for PD trials are required to improve efficiency and relevance.

Indexed as

outcomespatient-reported outcomesperitoneal dialysistrials

Identifiers

PMID34221389
PMCPMC8243273
OpenAlexW3116459216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.