Evidence map›Paper›PMID 34221379›Full record

ReviewClinical kidney journal2021

Fighting the unbearable lightness of neglecting kidney health: the decade of the kidney.

Raymond Vanholder, Lieven Annemans, Aminu K Bello, Boris Bikbov, Daniel Gallego, Ron T Gansevoort, Norbert Lameire, Valerie A Luyckx, Edita Noruisiene, Tom Oostrom and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 6 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 6 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Public Opinions on Removing Disincentives and Introducing Incentives for Organ Donation: Proposing a European Research Agenda.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Pooled it
  5. The efficacy and safety ofFrontiers in pharmacology · 2024
    Pooled it
  6. Pooled it
  7. Efficacy and safety of daprodustat in patients on peritoneal dialysis in the ASCEND-D trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Trial
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Kidney health for all: Caring for people, protecting the planet.Journal of family medicine and primary care · 2026
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Kidney Health for all: Caring for People, Protecting the Planet.Canadian journal of kidney health and disease · 2026
    Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 7 countries.

Raymond VanholderDepartment of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0003-2633-1636
Lieven AnnemansDepartment of Public Health and Primary Care, Ghent University, Ghent, Belgium.
Aminu K BelloDivision of Nephrology, Department of Medicine, University of Alberta, Edmonton, Canada.
Boris BikbovIstituto di Richerche Farmcologiche Mario Negri RICCS, Milan, Italy.
Daniel GallegoEuropean Kidney Patient Federation (EKPF), Dublin, Ireland.
Ron T GansevoortDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Norbert LameireDepartment of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, Ghent, Belgium.
Valerie A LuyckxDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Edita NoruisieneEuropean Dialysis and Transplant Nurses Association-European Renal Care Association (EDTNA/ERCA), Nidwalden, Switzerland.
Tom OostromDutch Kidney Foundation, Bussum, the Netherlands.
Christoph WannerDepartment of Internal Medicine I, Nephrology Section, Würzburg University, Würzburg University Hospital, Würzburg, Germany.
Fokko WieringaIMEC Eindhoven, Eindhoven, the Netherlands.
Ghent University Hospital · BEBrigham and Women's Hospital · USGhent University · BEImec the Netherlands · NLMario Negri Institute for Pharmacological Research · ITNierstichting · NLUniversitätsklinikum Würzburg · DEUniversity Medical Center Groningen · NLUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A brief comprehensive overview is provided of the elements constituting the burden of kidney disease [chronic kidney disease (CKD) and acute kidney injury]. This publication can be used for advocacy, emphasizing the importance and urgency of reducing this heavy and rapidly growing burden. Kidney diseases contribute to significant physical limitations, loss of quality of life, emotional and cognitive disorders, social isolation and premature death. CKD affects close to 100 million Europeans, with 300 million being at risk, and is projected to become the fifth cause of worldwide death by 2040. Kidney disease also imposes financial burdens, given the costs of accessing healthcare and inability to work. The extrapolated annual cost of all CKD is at least as high as that for cancer or diabetes. In addition, dialysis treatment of kidney diseases imposes environmental burdens by necessitating high energy and water consumption and producing plastic waste. Acute kidney injury is associated with further increases in global morbidity, mortality and economic burden. Yet investment in research for treatment of kidney disease lags behind that of other diseases. This publication is a call for European investment in research for kidney health. The innovations generated should mirror the successful European Union actions against cancer over the last 30 years. It is also a plea to nephrology professionals, patients and their families, caregivers and kidney health advocacy organizations to draw, during the Decade of the Kidney (2020-30), the attention of authorities to realize changes in understanding, research and treatment of kidney disease.

Indexed as

acute kidney injurychronic kidney diseasedialysisenvironmentepidemiologyhealth economykidney transplantationmortalitynon-communicable diseasesperitoneal dialysis

Identifiers

PMID34221379
PMCPMC8243275
OpenAlexW3156638771

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.