Evidence map›Paper›PMID 34221341›Full record

ArticleParkinson's disease2021

Central Pain in Parkinson's Disease: Behavioral and Cognitive Characteristics.

N Vila-Chã, S Cavaco, A Mendes, A Gonçalves, I Moreira, J Fernandes, J Damásio, L F Azevedo, J M Castro-Lopes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Exploring the effect and mechanism ofIBRO neuroscience reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

N Vila-ChãDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-3457-2328
S CavacoDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
A MendesDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
A GonçalvesDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
I MoreiraDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
J FernandesLaboratory of Neurobiology of Human Behavior, Centro Hospitalar Universitário do Porto, Porto, Portugal.
J DamásioDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.
L F AzevedoCentre for Health Technology and Services Research (CINTESIS), University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-8421-2937
J M Castro-LopesNational Observatory for Pain-NOPain, Faculty of Medicine, University of Porto, Porto, Portugal.
Universidade do Porto · PTCentro Hospitalar do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPain is a major nonmotor symptom of Parkinson's disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD. This study aimed to explore the cognitive and behavioral profile of PD patients with central parkinsonian pain.

resultsOne hundred and eighty-eight patients (68%) reported pain; and in 41 (22%) of them, the pain was classified as central parkinsonian pain. PD patients with central parkinsonian pain had better cognitive performance in DRS-2 Initiation/Perseveration and Conceptualization subscales but reported more other compulsive behaviors (e.g., hobbyism, punding, and walkabout) and had more current smoking habits than those without pain or with non-central parkinsonian pain. Multiple logistic regression analyses revealed that the DRS-2 Conceptualization subscale, other compulsive behaviors, and smoking habits remained statistically associated with central parkinsonian pain even when other significant covariates were considered. Only patients with pain, regardless of type, had a gambling disorder.

Identifiers

PMID34221341
PMCPMC8211520
OpenAlexW3168948135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.