Evidence map›Paper›PMID 34221339›Full record

ArticleGenome integrity2021

Conventional Risk Factors, Telomere Length, and Ischemic Heart disease: Insights into the Mediation Analysis.

Shobhit Piplani, Madhav Prabhu, Nadezdha Niyarah Alemao, C Akash, Pradhum Ram, Sameer Ambar, Vijay Kumbar, Yashasvi Chugh, Siba P Raychauduri, Sanjay Kumar Chugh

Open access · greenAbstract read
In one paragraph

Article in Genome integrity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Shobhit PiplaniIntern, KAHER, Belagavi, Karnataka, India.
Madhav PrabhuDepartment of General Medicine, KAHER, Belagavi, Karnataka, India.
Nadezdha Niyarah AlemaoDepartment of Radiology, M.V.J Medical College, Belagavi, Karnataka, India.
C AkashDepartment of Medicine, Jawaharlal Nehru Medical College, KAHER, Belagavi, Karnataka, India.
Pradhum RamDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
Sameer AmbarDepartment of Cardiology, KAHER, Belagavi, Karnataka, India.
Vijay KumbarResearch Officer, Maratha Mandal's N.G.H Institute of Dental Sciences & Research Centre, Belagavi, Karnataka, India.
Yashasvi ChughDepartment of Cardiology, Mount Sinai St. Luke's and West Hospitals, New York, United States.
Siba P RaychauduriDepartment of Medicine, University of California, Davis, United States.
Sanjay Kumar ChughDepartment of Cardiology, Jaipur National University Institute of Medical Sciences and Research Center, Jaipur, Rajasthan, India.
KLE University · INEmory University · USJaipur National University · INJawaharlal Nehru Medical College · INSt. Joseph's Hospital · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomere length is regarded as a potential biomarker of biological ageing and is associated with various age-related diseases, such as ischemic heart disease (IHD), myocardial infarction, peripheral vascular disease, and cancer. As there is a paucity of study that deals with this influence, this study aimed to assess how the cardiovascular risk factors influence the risk of IHD by performing mediation analysis. A total of 407 males were included in the study. IHD was diagnosed through echocardiography and coronary angiography by determining the number of coronary vessels involved. Demographic data, clinical history, and laboratory investigations such as random blood sugar (RBS), fasting lipid profile, serum creatinine, and serum urea levels of all the subjects were measured and recorded. Serum uric acid and blood urea nitrogen (BUN) levels were significantly higher in IHD subjects compared to non-IHD subjects (

Indexed as

Blood urea nitrogenischemic heart diseasereal-time polymerase chain reactionserum uric acidtelomere length

Identifiers

PMID34221339
PMCPMC8230014
OpenAlexW3172716017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.