Evidence map›Paper›PMID 34221246›Full record

ArticleJournal of cancer science & therapy2017

Clinical Significance of Disseminated Pluripotent Tumor Cell Signature Expression in the Bone Marrow from Patients with Colorectal Cancer.

Martin Gasser, Mia Kim, Roberta Rehder, Natasha Frank, Markus Frank, Tanja Grimmig, Romana Moench, Carmen Ribas, Bertram Illert, Christoph-Thomas Germer and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer science & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Martin Gasser *Department of Surgery I, University of Wuerzburg, Wuerzburg, Germany.
Mia Kim *Department of Surgery I, University of Wuerzburg, Wuerzburg, Germany.
Roberta RehderMedical School, Evangelic Faculty of Paraná, Curitiba, PR, Brazil.
Natasha FrankTransplantation Research Center, Children's Hospital Boston, Harvard Medical School, Boston, USA.
Markus FrankTransplantation Research Center, Children's Hospital Boston, Harvard Medical School, Boston, USA.
Tanja GrimmigDepartment of Surgery I, Molecular Oncology and Immunology, University of Wuerzburg, Wuerzburg, Germany.
Romana MoenchDepartment of Surgery I, Molecular Oncology and Immunology, University of Wuerzburg, Wuerzburg, Germany.
Carmen RibasMedical School, Evangelic Faculty of Paraná, Curitiba, PR, Brazil.
Bertram IllertDepartment of Surgery I, University of Wuerzburg, Wuerzburg, Germany.
Christoph-Thomas GermerDepartment of Surgery I, University of Wuerzburg, Wuerzburg, Germany.
Andreas RosenwaldInstitute of Pathology, University of Wuerzburg, Germany.
Ana Maria Waaga-GasserDepartment of Surgery I, Molecular Oncology and Immunology, University of Wuerzburg, Wuerzburg, Germany.
University of Würzburg · DEBoston Children's Hospital · USBrigham and Women's Hospital · US

Funding

Immunology of human malignant melanoma initiating cellsR01CA158467 · NCI · BOSTON CHILDREN'S HOSPITAL · PI FRANK, MARKUS H., HODI, FRANK S · 2012 to 2016
$1.9M
NCI NIH HHS R01 CA158467
6 · The paper itself

Abstract

purposeDisseminated tumor cells (DTCs) are critically involved in tumor relapse and survival in several invasive tumors. We previously showed that the ATP-binding cassette (ABC) transporter,

methodsThis study included 49 consecutive patients (UICC stage I-IV) that underwent curatively intended or palliative surgery for CRC. We analyzed cells from bone marrow aspirates obtained before surgery and derived from patients that had completed minimally a 5-year follow-up. The gene expression of

resultsBone marrow analysis showed differential expression between the analyzed genes.

conclusionOverexpression of

Indexed as

ABCB5Bone marrowCancer initiating cellsColorectal cancerDisseminated tumor cells

Identifiers

PMID34221246
PMCPMC8248589
OpenAlexW2768031140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.