ArticleDisease markers2021
Altered Small-World Functional Network Topology in Patients with Optic Neuritis: A Resting-State fMRI Study.
Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Topological Organization Alterations of Whole-Brain Functional Networks in Patients with Childhood Absence Epilepsy: Associations with Treatment Effects.Disease markers · 2021Trial
- Abnormal topological properties and functional-structural coupling of large-scale brain networks in primary angle-closure glaucoma.Quantitative imaging in medicine and surgery · 2025Article
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- Frequency-specific segregation and integration of human cerebral cortex: An intrinsic functional atlas.iScience · 2024Article
- [Changes of brain network in patients with insomnia following radiotherapy for cervical cancer and their correlation with IT-TMS treatment efficacy: a graph-theory analysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Topological properties and connectivity patterns in brain networks of patients with refractory epilepsy combined with intracranial electrical stimulation.Frontiers in neuroscience · 2023Article
- Frequency-Specific Analysis of the Dynamic Reconfiguration of the Brain in Patients with Schizophrenia.Brain sciences · 2022Article
- Comparison of frontostriatal circuits in adolescent nicotine addiction and internet gaming disorder.Journal of behavioral addictions · 2022Review
- Efficacy of acupuncture at ghost points combined with fluoxetine in treating depression: A randomized study.World journal of clinical cases · 2022Article
- Graph-Theory-Based Degree Centrality Combined with Machine Learning Algorithms Can Predict Response to Treatment with Antipsychotic Medications in Patients with First-Episode Schizophrenia.Disease markers · 2022Article
- Altered Brain Activity in Patients With Comitant Strabismus Detected by Analysis of the Fractional Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study.Frontiers in human neuroscience · 2022Article
- Brain Network Topology and Structural-Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition.Frontiers in neuroscience · 2022Article
- Improved Functional Organization in Patients With Primary Insomnia After Individually-Targeted Transcranial Magnetic Stimulation.Frontiers in neuroscience · 2022Article
- Reduced thalamic resting-state functional connectivity and impaired cognition in acute abstinent heroin users.Human brain mapping · 2021Article
- Abnormal Static and Dynamic Functional Connectivity in Left and Right Temporal Lobe Epilepsy.Frontiers in neuroscience · 2021Article
- Classifying Vulnerability to Sleep Deprivation Using Resting-State Functional MRI Graph Theory Metrics.Frontiers in neuroscience · 2021Article
- Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis.Frontiers in neuroscience · 2021Article
- Effect of the cPKCγ-Ng Signaling System on Rapid Eye Movement Sleep Deprivation-Induced Learning and Memory Impairment in Rats.Frontiers in psychiatry · 2021Article
- Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study investigated changes in small-world topology and brain functional connectivity in patients with optic neuritis (ON) by resting-state functional magnetic resonance imaging (rs-fMRI) and based on graph theory.
methodsA total of 21 patients with ON (8 males and 13 females) and 21 matched healthy control subjects (8 males and 13 females) were enrolled and underwent rs-fMRI. Data were preprocessed and the brain was divided into 116 regions of interest. Small-world network parameters and area under the integral curve (AUC) were calculated from pairwise brain interval correlation coefficients. Differences in brain network parameter AUCs between the 2 groups were evaluated with the independent sample
resultsIn the sparsity range from 0.08 to 0.48, both groups exhibited small-world attributes. Compared to the control group, global network efficiency, normalized clustering coefficient, and small-world value were higher whereas the clustering coefficient value was lower in ON patients. There were no differences in characteristic path length, local network efficiency, and normalized characteristic path length between groups. In addition, ON patients had lower brain functional connectivity strength among the rolandic operculum, medial superior frontal gyrus, insula, median cingulate and paracingulate gyri, amygdala, superior parietal gyrus, inferior parietal gyrus, supramarginal gyrus, angular gyrus, lenticular nucleus, pallidum, superior temporal gyrus, and cerebellum compared to the control group (
conclusionPatients with ON show typical "small world" topology that differed from that detected in HC brain networks. The brain network in ON has a small-world attribute but shows reduced and abnormal connectivity compared to normal subjects and likely causes symptoms of cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.