ArticleAnimal reproduction2018
Parthenogenetic bovine embryos secrete type I interferon capable of stimulating
Article in Animal reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Irisin Modulates IFNT Signaling in Bovine Luteal Cells.Molecular reproduction and development · 2025Article
- Conceptus signaling markers in immune cells enhance pregnancy prediction in beef cattle.Scientific reports · 2025Article
- Characterization of Serum Metabolome and Proteome Profiles Identifies SNX5 Specific for Pregnancy Failure in Holstein Heifers.Life (Basel, Switzerland) · 2022Article
- Conceptus-modulated innate immune function during early pregnancy in ruminants: a review.Animal reproduction · 2021Review
- Profiles of progesterone and bovine interferon-τ in repeat breeding and non-repeat breeding Aceh cows.Veterinary world · 2021Article
- Early pregnancy-induced transcripts in peripheral blood immune cells in Bos indicus heifers.Scientific reports · 2020Article
- Extracellular Vesicles Mediated Early Embryo-Maternal Interactions.International journal of molecular sciences · 2020Review
- The pre-hatching bovine embryo transforms the uterine luminal metabolite composition in vivo.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interferon tau (IFNT) is the pregnancy recognition signal in ruminants and is secreted by trophoblast cells. Paracrine action in the endometrium is well established by inhibiting luteolytic pulses of prostaglandin F2 alpha. Recently, endocrine action was documented in the corpus luteum, blood cell and liver. It was hypothesized that conditioned medium (CM) obtained from days 7, 9 and 12 parthenogenetic embryos alters luteal cell gene expression. The aim was to establish a bovine mixed luteal cell culture to evaluate cellular response associated to interferon stimulated genes, steroidogenesis and apoptosis. Conditioned medium was obtained from Days 7, 9 and 12 parthenogenetic (PA) embryos culture. Moreover, antiviral assay was performed on CM from Days 7, 9 and 12 to verify Type I interferon activity. Luteal cell culture was validated by steroidogenic and apoptotic genes (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.